Synchronized Intermittent Mechanical Ventilation Versus Open Lung Ventilation With Spontaneous Respiration
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | October 2007 |
| Contact: | Jonathan L Marinaro, MD |
| Email: | jmarinaro@salud.unm.edu |
| Phone: | 5052726248 |
Synchronized Intermittent Mechanical Ventilation vs Open Lung Ventilation With Spontaneous Respiration
The purpose of this study is to collect data on patients who are on breathing machines
(ventilators) in the Trauma Surgical Intensive Care Unit (TSICU). This data may help us to
determine if one form of assisted breathing is better than another. The two forms of
assisted breathing being compared in this study are called BiVent and SIMV. (7) BiVent and
SIMV are both delivered by a ventilator but differ in how they assist breathing. SIMV is an
older form of mechanical breathing that blows air into the lungs to inflate the lungs.
BiVent is a newer form of mechanical ventilation that permits the patient to pull air into
the lungs as we normally do. Both BiVent and SIMV are currently being used on a regular
basis in the TSICU. The investigators hope that this study will determine if one method of
assisted breathing is better than another in preventing complications associated with
mechanically assisted breathing.
(ventilators) in the Trauma Surgical Intensive Care Unit (TSICU). This data may help us to
determine if one form of assisted breathing is better than another. The two forms of
assisted breathing being compared in this study are called BiVent and SIMV. (7) BiVent and
SIMV are both delivered by a ventilator but differ in how they assist breathing. SIMV is an
older form of mechanical breathing that blows air into the lungs to inflate the lungs.
BiVent is a newer form of mechanical ventilation that permits the patient to pull air into
the lungs as we normally do. Both BiVent and SIMV are currently being used on a regular
basis in the TSICU. The investigators hope that this study will determine if one method of
assisted breathing is better than another in preventing complications associated with
mechanically assisted breathing.
SOLV Hypothesis:
A prospective, randomized trial directly comparing open lung ventilation (OLV) with
spontaneous breathing (SB) utilizing BiVent on the Maquet Servo-I versus synchronized
intermittent mechanical ventilation (SIMV) will be conducted in the trauma-surgical
intensive care unit at the University Hospital (TSICU). Both OLV-SB and SIMV protocols have
been designed according to lung protective strategies. The primary goal of the SOLV trial is
to see determine if the early application of open lung ventilation will less ventilator
days. In addition, several secondary endpoints will be evaluated. It is not anticipated that
this study will be powered to show a mortality difference.
A prospective, randomized trial directly comparing open lung ventilation (OLV) with
spontaneous breathing (SB) utilizing BiVent on the Maquet Servo-I versus synchronized
intermittent mechanical ventilation (SIMV) will be conducted in the trauma-surgical
intensive care unit at the University Hospital (TSICU). Both OLV-SB and SIMV protocols have
been designed according to lung protective strategies. The primary goal of the SOLV trial is
to see determine if the early application of open lung ventilation will less ventilator
days. In addition, several secondary endpoints will be evaluated. It is not anticipated that
this study will be powered to show a mortality difference.
Inclusion Criteria:
- >/=18 years of age, ISS >/=25, on ventilator for more than 48 hours
Exclusion Criteria:
- less than 18 years of age, die or come off ventilator in less than 48 hours
We found this trial at
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