Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)



Status:Recruiting
Conditions:Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology
Healthy:No
Age Range:Any - 16
Updated:8/11/2018
Start Date:October 2003
End Date:July 2023
Contact:Susan Furth, MD, PhD
Email:FurthS@email.chop.edu
Phone:215-590-2449

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The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute
of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the Eunice
Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the
National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement including two
Clinical Coordinating Centers (at Children's Hospital of Philadelphia and at Children's Mercy
Hospital in Kansas City), a central biochemistry laboratory (at the University of Rochester)
and a Data Coordinating Center (at Johns Hopkins School of Public Health) to conduct a
prospective epidemiological study of children with chronic kidney disease (CKD).

Since its inception in 2003, the scientific aims of CKiD have been to determine the risk
factors for decline in kidney function and to define how progressive decline in kidney
function impacts biomarkers of risk factors for cardiovascular disease; neurocognitive
function and behavior; and growth failure and its associated morbidity.

Inclusion Criteria:

- Age between 1 and 16 years (before 17th birthday) for Cohorts 1 and 2; age between 6
months and 16 years (before 17th birthday) for Cohort 3

- Estimated (based on SCr) Schwartz GFR between 30 and 90 ml/min|1.73m2 for Cohort 1 OR
an estimated GFR between 45 and 90 ml/min|1.73m2 based on the updated Schwartz formula
for Cohort 2

- Willingness and ability to provide informed consent and assent

- For Cohort 3, children with non-glomerular diagnosis and duration of kidney disease
less than 5 years will be enrolled.

Exclusion Criteria:

- Renal, other solid organ, bone marrow or stem cell transplantation

- Dialysis treatment within the past three months

- Cancer diagnosis or HIV diagnosis/treatment within last twelve months

- Current pregnancy or pregnancy within past twelve months

- Inability to complete major data collection procedures

- Current enrollment in a randomized clinical trial in which the specific treatment is
unknown

- Not fluent in English or Spanish

- Plans to move out of area of any participating CKiD site (Families can be transferred
to another CKiD site if they move)

- History of structural heart disease

- Genetic syndromes involving the central nervous system (e.g., Downs syndrome)

- History of severe to profound mental retardation (i.e., intelligence quotient (IQ)<40,
significant impairment in adaptive function and/or inability to independently execute
self-care skills)

- For cohort 3, children who are expected to receive renal replacement therapy within 6
months of date of enrollment will not be recruited
We found this trial at
2
sites
2401 Gillham Road
Kansas City, Missouri 64108
Principal Investigator: Bradley Warady, MD
Phone: 816-234-3812
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Principal Investigator: Susan Furth, MD, PhD
Phone: 215-590-2449
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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