The University of Chicago Comprehensive Cancer Center (UCCCC) is committed to exploring and developing innovative ways to prevent and reduce cancer's devastating effects through a collaborative research program involving 210 renowned scientists and physician scientists.

UChicago established the UCCCC in 1973 following approval of the National Cancer Act, which strengthened efforts of the National Cancer Institute (NCI). Through its Cancer Centers Program, NCI currently supports 65 cancer centers — 41 of which, including the UCCCC, are Comprehensive Cancer Centers distinguised by "scientific excellence and the capability to integrate a diversity of research approaches to focus on the problem of cancer." Comprehensive Cancer Centers share a common goal — to attack malignant diseases through laboratory research, innovative clinical trials, and prevention research.

The UCCCC is one of only two NCI-designated Comprehensive Cancer Centers in Illinois and has earned a reputation for excellence, innovation, and a commitment to addressing cancer from every angle. In 2011, the Commission on Cancer of the American College of Surgeons gave the UChicago cancer program the highest accreditation—a 3-Year Accreditation Award with Commendation.

UCCCC scientists study disease at the molecular level to evaluate how minute variations in genes can trigger processes that initiate abnormal cell growth. Clinical researchers apply the knowledge discovered in the laboratory to create and test promising new treatments and procedures. They bring patients new hope as they test novel therapies for effectiveness and determine optimal dosages. Clinicians and investigators, who specialize in cancer control, prevention, and population research, implement new approaches to screening and prevention, teach state-of-the-art diagnostics to local physicians, and work with local communities to encourage residents to adopt healthier lifestyles and to recognize the value of cancer screening and early detection. Our community researchers also strive to eliminate health disparities among ethnic and social groups.