Presence St. Mary's, originally known as the Emergency Hospital, was opened in March 1897 by the Sister Servants of the Holy Heart of Mary. In 1925, it was re-named St. Mary's Hospital. In 1997, the Servants of the Holy Heart of Mary combined with the Franciscan Sisters of the Sacred Heart and Sisters of Mercy of Americas to form Provena Health and the hospital name changed to Provena St. Mary's Hospital. This merger allowed the hospital to expand its services and increase the level of complete health care. In 2011, Provena Health merged with the Resurrection Health Care system to form what it is now called Presence Health. This merger changed the hospital name to Presence St. Mary's Hospital.

Presence St. Mary's Hospital is a 186 bed acute care facility with a Level II Emergency/Trauma Center. Presence St. Mary's Hospital provides many health care services such as a Regional Cancer Center, Rehabilitation Services, Family Birthing Center, Pediatric Unit, Mental Health Services, Sleep Diagnostic Centre, Breast Health Center, Renal Dialysis Centre, Accredited Chest Pain Center, Wound Care, Infusion Center, Breast Health Center, Occupational Health, MedSpa and a Total Fitness Center.