For well over a decade, L-MARC Research Center has been involved in metabolic clinical research and has conducted over 300 Phase I through IV clinical trials including:

• Cardiovascular - Hyperlipidemia, hypertension, atherosclerosis
• Endocrine/Metabolic - Obesity, type 2 diabetes mellitus, lipid disorders, osteoporosis, hormone replacement therapy for menopause, thyroid disorders, hypertension
• Musculoskeletal - Osteoarthritis, osteoporosis, rheumatoid arthritis
• For a listing of past and current clinical trials, please visit L-MARC Research Center's website at www.lmarc.com.

Harold E. Bays MD, FACP

Harold Bays, MD, FACP is Medical Director and President of Louisville Metabolic and Atherosclerosis Research Center (L-MARC) and continues to see oversee patient care for Louisville Endocrinology P.S.C., - a private medical practice in Louisville, Kentucky. Dr. Bays received his medical degree, completed his Internship and Residency in Internal Medicine, and received his Fellowship in Endocrinology and Metabolism all at the University of Louisville School of Medicine. He is board certified in both Internal Medicine and Endocrinology and Metabolism.

Dr. Bays has served as a Principal Investigator for over 400clinical trials, including studies of all currently marketed lipid-altering drug treatments, as well as studies of investigational drugs for obesity, diabetes mellitus, hypertension, osteoporosis, osteoarthritis, and other metabolic disorders. He has written, or has been a contributing author to over 250 published peer-reviewed scientific manuscripts, abstracts, and medical/scientific book chapters. Specifically, he has been a published author in journals such as: Obesity Research, Journal of Clinical Endocrinology and Metabolism, Medical Clinics of North America, Metabolism, Drug Development & Research, Circulation, Atherosclerosis, Expert Opinion on Investigational Drugs, Journal of Cardiovascular Therapy, Expert Opinion on Pharmacotherapy, Progress in Drug Research, Journal of Clinical Pharmacology, American Journal of Cardiology, Drug Safety, Clinical Therapeutics, Journal of Clinical Investigations in Arteriosclerosis, American Journal of Kidney Disease, American Journal of Cardiovascular Drugs, Preventive Cardiology, Expert Review of Cardiovascular Therapy, Evidence-based Cardiovascular Medicine, European Heart Journal, Clinical Cardiology, Future Cardiology, International Journal of Clinical Practice, Coronary Artery Disease, Hospital Pharmacy Europe, Nature Clinical Practice Cardiovascular Medicine, Nutrition Metabolism & Cardiovascular Disease, Journal of Women's Health, and is a scientific contributor to www.lipidsonline.org.

Dr. Bays originated the term "adiposopathy", which is defined as pathogenic adipose tissue which is promoted by positive caloric balance and sedentary lifestyle in genetically and environmentally susceptible patients, which may be anatomically manifested by adipocyte hypertrophy, visceral adipose tissue accumulation, and ectopic fat deposition, and physiologically results in adverse metabolic and immune consequences resulting in clinical metabolic disease. He has published several manuscripts on the adipocentric paradigm wherein pathogenic adipose tissue represents a rational, unifying cause of excessive fat-related metabolic diseases. Dr. Bays is Chairman of the American Association of Clinical Endocrinologists (AACE) Task Force on Pathogenic Adipose Tissue and Metabolic Disease. Dr. Bays is also Chairman of the study group overseeing the "Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes" (SHIELD), which is the largest survey of its kind, designed as a cross-sectional and subsequent longitudinal study of various parameters relevant to metabolic diseases, including diabetes mellitus.

He has served as an expert manuscript reviewer for scientific medical journals including: Journal of the American Medical Association (JAMA), The Lancet, Archives of Internal Medicine, Obesity Research/Obesity, Journal of the American College of Cardiology (JACC), Methods and Findings in Experimental and Clinical Pharmacology, Opinion in Molecular Therapeutics, Annuals of Nutrition and Metabolism, Biochemical Pharmacology, Vascular Health and Risk Management, Drug Discovery Today, Investigational Drug Database, Trends in Pharmacological Sciences, Expert Opinion on Biologic Therapy, Drugs, Journal of the American College of Nutrition, American Journal of Cardiovascular Drugs, Expert Opinion on Pharmacotherapy, Expert Opinion on Investigational Drugs, International Journal of Clinical Practice, Pharmacological Research, Expert Opinion on Drug Safety, Consultant, Future Lipidology, Nature Clinical Practice Cardiovascular Medicine, Expert Opinion on Therapeutic Targets, Treatments in Endocrinology, Journal of Clinical Outcomes Management, Vascular Health and Risk Management, and Journal of Cardiovascular Drugs.. Dr. Bays has presented poster abstracts and/or given oral presentations of abstracts regarding cardiovascular disease, obesity, and diabetes mellitus at various scientific meetings, international symposia, and university conferences.

Finally, Dr. Bays serves as a national and international advisor and consultant for pharmaceutical companies in protocol and drug project development, and has given hundreds of invited educational presentations, including Continuing Educational Education (CME) programs.

Dr. Bays is a Fellow of the North American Association for the Study of Obesity (NAASO) and a Fellow of the American College of Physicians (FACP). He is a member of the American Diabetes Association (ADA) - and has been a “Recognized” provider in the ADA's NCQA Diabetes Physician Recognition Program since 1998. Dr. Bays is also a member of the American Association of Clinical Endocrinologists (AACE), the American Society of Bariatric Physicians (ASBP), the American Medical Association (AMA), the Kentucky Medical Association (KMA) and has been honored with academic awards, as well as for his longstanding physician volunteer work for the homeless.

Sarah Keiran RN, BSN, CCRC
Senior Clinical Research Coordinator
10 years experience in clinical research

Becky Whitehead RN, BSN, CCRC
Senior Clinical Research Coordinator
9 years experience in clinical research

Carolyn Williams RD, LD, CCRC
Senior Clinical Research Coordinator
2 years experience in clinical research

Kathy Schmitz RD, LD CRC
Clinical Research Coordinator
1 year experience in clinical research

Maureen McAllister, ARNP, CCRC
Sub Investigator/Certified Clinical Research Coordinator
3 years experience in clinical research

Barbara Michelle Ritchey, ARNP, CRC
Sub Investigator/Clinical Research Coordinator
2 years experience in clinical research

Frank A. Walker, MD
Sub Investigator
40 years experience in clinical research

Jean Micklewright RD, LD
Director of Dietary Programs / Research Dietitian
8 years experience in clinical research

Tammy Jackson
Clinical Research Laboratory
6 years experience in clinical research

Christina Shelton
Clinical Research Laboratory
5 years experience in clinical research

Debbie Conliffe BS
Research Assistant
7 years experience in clinical research

Kathy Roberts
Electronic Data Capture / Research Administrative Assistant
6 years experience in clinical research

Jerry Seadler
Environmental Services

Brian Dawson RN, BSN
Site Manager
6 years experience in clinical research

L-MARC is located in Louisville which is the largest city in the Commonwealth of Kentucky. Louisville is located across the Ohio River from Indiana, therefore allowing for large populations of study volunteers from several counties in southern Indiana as well as surrounding counties in Kentucky. The Louisville metropolitan area is comprised of seven counties (three in Kentucky and four in Indiana) with a population of 1.2 million. A good number of study volunteers are willing to travel to Louisville from rural parts of the state to participate in clinical trials. With its central location, L-MARC attracts subjects of various socioeconomic class, ethnic background, race and gender. L-MARC has a data base of research volunteers in the Study Manager program that can be accessed for patient recruitment.

Cardiology/Vascular Diseases
Endocrinology
Musculoskeletal
Nephrology/Urology
Neurology
Obstetrics/Gynecology
Pulmonary/Respiratory Diseases
Rheumatology