GRCOP initially formed to develop community cancer patient management guidelines. In 1983 GRCOP changed its focus to become one of the first participants in the National Cancer Institute (NCI) Community Clinical Oncology Program (CCOP), offering national clinical trials through a community-based clinical research program.

GRCOP offers local access to, and data management support for, over 150 cancer research studies. GRCOP works with local hospitals and cancer organizations in providing the highest quality care for cancer prevention and treatment. GRCOP continues to provide access to the latest cancer research both nationally and locally.