Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | April 2008 |
| End Date: | April 2011 |
| Contact: | Anju Nohria, MD |
| Email: | anohria@partners.org |
| Phone: | 617 525-6852 |
The Effect of Fasudil on Rho Kinase Activity in Patients Scheduled for Elective Carotid Endarterectomy
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of
vascular dysfunction in patients with atherosclerosis.
vascular dysfunction in patients with atherosclerosis.
Inclusion Criteria:
- Subjects with >= 70% carotid stenosis (unilateral or bilateral) who are scheduled to
undergo elective carotid endarterectomy
- Age >= 18 years
- Agreement of the operating surgeon for patient to participate
Exclusion Criteria:
- Surgery scheduled < 14 days after randomization
- Pregnancy
- ALT, GGT > 3x upper limit of normal (ULN)
- Creatinine > 3.5 mg/dL
- Prior intolerance to statins
- Reluctance to add or change dosage of statin therapy during study
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