Magnetic Resonance Imaging (MRI) Ofl Volunteers

Technical evaluation of magnetic resonance imaging and spectroscopy will be performed on
subjects who are eligible and willing to volunteer to have a research MRI performed. These
studies may involve the intravenous administration of commercially available MR contrast
media. Some scans may require inhaled carbogen (95% oxygen and 5% carbon dioxide) and
hyperoxia (100% oxygen) as a contrast media. The results will be used to evaluate the
performance of various pulse sequences, gradient coils, and rf coils on human subjects and
will provide essential ground work for specific patient protocols.

- INCLUSION CRITERIA:

Any subject above the age of 18 who is capable of giving informed consent.

This study allows for the enrollment of healthy volunteers as well as volunteers with
disease for the purpose of continued technical development in a wide variety of conditions.

EXCLUSION CRITERIA:

A subject will be excluded if he/she has a contraindication to MR scanning implanted metal
clips or wires of the type which may concentrate radiofrequency fields or cause tissue
damage from twisting in a magnetic field.

Examples include:

1. Aneurysm clip

2. Implanted neural stimulator

3. Implanted cardiac pacemaker or autodefibrillator

4. Cochlear implant

5. Ocular foreign body (e.g., metal shavings)

6. Any implanted device (pumps, infusion devices, etc)

7. Shrapnel injuries

8. All employees/staff supervised by the Principal Investigator or an Associate
Investigator are excluded from participation.

To assess whether subjects are normal eligible to participate, they will be asked to fill
out a questionnaire. Subjects will be excluded if it is deemed that they have a condition
which would preclude their use for technical development (e.g. paralyzed hemidiaphragm,
morbid obesity, claustrophobia etc.) or present unnecessary risks (e.g. pregnancy, surgery
of uncertain type, symptoms of pheochromocystoma or insulinoma, etc.). Lactating women and
subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from
studies involving the administration of contrast agents.

To assess whether subjects are eligible to participate in a GBCA study, before undergoing a
GBCA imaging study, volunteers will be asked whether or not they have received a MRI with
contrast at an outside institution within the last 6 months and have their Clinical Center
medical records reviewed. To track exposures to intravenous GBCAs, for each subject we are
administrating GBCA, we will maintain a database recording any reports of GBCA
administration at an outside institution and the running total of GCBA administration at
the Clinical Center. Volunteers who have had exposure to intravenous GBCAs within the last
6 months at an outside institution or the Clinical Center, or reached their maximum of 4
GBCA research imaging studies during their study participation on this protocol, will be
excluded from having a contrast enhanced MRI, but will not be excluded from the protocol
for non-contrasted MRI studies.

To ensure volunteers who have renal failure do not undergo a GBCA imaging study, all
volunteers who will receive Gadolinium based contrast agents will have a serum Creatinine
obtained within one week of the MRI examination. All subjects with a calculated eGFR < 60
will be excluded from having a contrast enhanced MRI, but will not be excluded from the
protocol for non-contrasted MRI studies.