Dietary Lutein and the Retinopathy of Prematurity
| Status: | Completed |
|---|---|
| Conditions: | Ocular, Women's Studies |
| Therapuetic Areas: | Ophthalmology, Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | August 2005 |
| End Date: | August 2009 |
| Contact: | Sonja L Connor, MS |
| Email: | connors@ohsu.edu |
| Phone: | 503-494-7775 |
The Placental and Mammary Transfer of Lutein and Zeaxanthin Into the Fetus and the Breast-Fed Infant
The clinical trial aspect of this study is the provision of a lutein supplement to lactating
women and compare the amount of lutein in the milk and blood with lactating women who do not
receive the lutein supplement.
women and compare the amount of lutein in the milk and blood with lactating women who do not
receive the lutein supplement.
About one-fourth of preterm infants who weight less than 2 3/4 pounds at birth develop an
eye problem. This problem occurs in the retina (back of the eye) and may result in
blindness. This eye problem is called the retinopathy of prematurity(ROP). There are two
yellow pigments in the retina called lutein and zeaxanthin. These pigments may protect the
retina from being damaged by light. They may also protect the retina from being damaged by
oxygen. These pigments are transferred from the mother to the baby. Most of this takes place
during the last trimester of pregnancy. The situation could be worse if the baby receives
formula. Most baby formulas do not contain lutein and zeaxanthin; breast milk does. Another
worry is that breast milk may not have enough lutein and zeaxanthin if the mother does not
eat enough vegetables and fruits. The purpose of this study is to measure the transfer of
lutein and zeaxanthin from the mother to the baby, to measure the amount of lutein and
zeaxanthin in breast milk, to find out if taking a lutein supplement will increase the
amount of lutein in breast milk and to find out if dietary lutein and zeaxanthin are
involved in the development of the retinopathy of prematurity (ROP).
eye problem. This problem occurs in the retina (back of the eye) and may result in
blindness. This eye problem is called the retinopathy of prematurity(ROP). There are two
yellow pigments in the retina called lutein and zeaxanthin. These pigments may protect the
retina from being damaged by light. They may also protect the retina from being damaged by
oxygen. These pigments are transferred from the mother to the baby. Most of this takes place
during the last trimester of pregnancy. The situation could be worse if the baby receives
formula. Most baby formulas do not contain lutein and zeaxanthin; breast milk does. Another
worry is that breast milk may not have enough lutein and zeaxanthin if the mother does not
eat enough vegetables and fruits. The purpose of this study is to measure the transfer of
lutein and zeaxanthin from the mother to the baby, to measure the amount of lutein and
zeaxanthin in breast milk, to find out if taking a lutein supplement will increase the
amount of lutein in breast milk and to find out if dietary lutein and zeaxanthin are
involved in the development of the retinopathy of prematurity (ROP).
Inclusion Criteria:
- Planning to breast feed for at least 12 weeks
- Willing to be randomized to take the lutein supplement
Exclusion Criteria:
- Insufficient quantity of breast milk
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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