Study Investigating MEN1 and SDHD in Familial Carcinoid Tumors



Status:Completed
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:12 - Any
Updated:4/2/2016
Start Date:April 2008
End Date:June 2010
Contact:Nancy Gardner, PhD
Email:gardnern@rutgers.edu
Phone:813-731-0894

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Trial Summary
Trial Overview
Inclusion Criteria

A Pilot Study to Investigate Germ-Line MEN1 and SDHD Gene Mutation in Familial Cases of Carcinoid Cancer

There is a high incidence among the first degree relatives of the carcinoid patients,
indicating the involvement of genetic components in its initiation and pathogenesis.

This proposed pilot study will conduct detailed interviews into the medical, environmental,
and family histories and to collect blood specimen to obtain DNA. The Blood specimen and DNA
will be processed by the Rutgers University Cell and DNA Repository (RUCDR) to rule out
Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit
D (SDHD), gene inactivation thought to be associated with different types of carcinoid
cancer.

Inclusion Criteria:

1. Over the age of 18 years

2. More than one ,member of a family with a history of biopsy confirmed carcinoid tumor

3. English speaking

4. Mentally and emotionally capable of answering questions

5. Willing and available for study participation

6. At least one other family member with carcinoid tumor

Exclusion Criteria:

1. If you are under the age of 18 years,

2. If you are unable to understand or unable to provide informed consent,

3. If you have a psychological condition (i.e. depression, anxiety disorder, substance
abuse, etc.) which might cause you significant problems in dealing with test results.
We found this trial at
1
site
Busch Campus of Rutgers University, Human Genetics Institute
Piscataway, New Jersey 08854
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mi
from
Piscataway, NJ
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