Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness

Inclusion Criteria:

- Is an adult 18 years of age or older

- Has a diagnosis of advanced illness (ie, a terminal illness such as incurable cancer
or other end-stage disease)

- Has a life expectancy of at least 1 month.

- Is receiving opioids on a regular schedule (not just as-needed or rescue doses) for
the control of pain or discomfort for at least 2 weeks before the first dose of study
drug.

- Has constipation that is caused by opioid medications.

Exclusion Criteria:

- Has a known or suspected allergy to methylnaltrexone or other similar compounds (e.g.
naltrexone or naloxone).

- Has a known or suspected mechanical gastrointestinal obstruction.

- Has any potential nonopioid cause of bowel dysfunction that might be a major
contributor to the constipation.

- Has any other clinically important abnormalities as determined by the investigator
that may interfere with his or her participation in or compliance with the study.

- Receiving opioid antagonist or partial antagonist products.