Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/8/2014 |
| Start Date: | October 2007 |
| End Date: | December 2013 |
| Contact: | Michael W Donnino, MD |
| Email: | mdonnino@bidmc.harvard.edu |
| Phone: | 617-754-2295 |
Corticosteroids Therapy in Refractory Shock Following Cardiac Arrest
The major goal of this project is to determine whether the use of physiologic doses of
corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and
alters microcirculatory flow in post-cardiac arrest patients.
corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and
alters microcirculatory flow in post-cardiac arrest patients.
Inclusion Criteria:
- Greater than 18 years old
- Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with
resultant ROSC
- Vasopressor dependent for a minimum of 1 hour post-arrest
Exclusion Criteria:
- Pregnant
- Indication for Corticosteroids outside of current research proposal
- DNR or comfort care measures
- Presence of septic shock
- Chronic Use (>1week) of oral Corticosteroids in the last year
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