Statin Therapy in the Treatment of Sepsis
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2008 |
| End Date: | December 2010 |
Study of Statin Therapy in the Treatment of Sepsis
Simvastatin will attenutat IL-6 levels and lead to a more rapid shock reversal than placebo
Inclusion Criteria:
- Greater than 18 years old
- Hypotensive requiring vasopressors
- Suspected Infection
Exclusion Criteria:
- Pregnant
- Liver Failure (ALT or AST > 120)
- Rhabomyolysis (CPK > 3x normal)
- Comfort care measures status
- Chronic Liver Disease (Cirrhosis)
- Use of Cyclosporin, Digoxin, Statins
- Patients who are unable to take medications by mouth or NGT
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Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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