Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain
| Status: | Completed |
|---|---|
| Conditions: | Angina, Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Gastroenterology |
| Healthy: | No |
| Age Range: | 5 - 17 |
| Updated: | 4/21/2016 |
| Start Date: | December 2006 |
| End Date: | October 2015 |
Capsaicin-sensitive Transient Receptor Potential Vanilloid One (TRPV1) and Tyrosine Kinase (TrkA) Receptor Expression in Children With Retrosternal Pain
We would like to evaluate the changes in nerve innervation and TRPV1 receptor expression
along with microscopic changes associated with heart burn and abdominal pain
along with microscopic changes associated with heart burn and abdominal pain
Approximately 5% of children between 10-17 years of age report symptoms of heart burn,
epigastric pain or regurgitation. This study will evaluate the changes in nerve innervation
and TRPV1 receptor expression in children having upper endoscopy for evaluation of heart
burn and abdominal pain.
epigastric pain or regurgitation. This study will evaluate the changes in nerve innervation
and TRPV1 receptor expression in children having upper endoscopy for evaluation of heart
burn and abdominal pain.
Inclusion Criteria:
- Retrosternal and/or epigastric pain and esophagitis
- Retrosternal and/or epigastric pain but no macroscopic or microscopic esophagitis
- Gastrointestinal symptoms such as diarrhea, regurgitation, rumination, vomiting,
feeding aversion, non-organic failure to thrive, celiac disease with no macroscopic
or microscopic esophageal inflammation
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Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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