Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS) |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 10 - 18 |
| Updated: | 4/17/2018 |
| Start Date: | June 2007 |
| End Date: | January 2019 |
Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation Following Rectal Stimulation in Children With Irritable Bowel Syndrome
The purpose of the study is to map regions of brain activation following rectal stimulation
in children with irritable bowel syndrome (IBS) and healthy controls.
in children with irritable bowel syndrome (IBS) and healthy controls.
Our first aim is to compare the brain areas activated rectal stimulation in boys and girls
with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain
activated during rectal stimulation in pre and post-pubertal male and female subjects between
10-18 yrs of age.
with IBS and healthy children. Our second aim is to compare the anatomic regions of the brain
activated during rectal stimulation in pre and post-pubertal male and female subjects between
10-18 yrs of age.
Inclusion Criteria:
- Children aged 10 years to 18 years who provide written assent and whose parents
provide written permission for participation
- English-speaking
- Subjects in the IBS group will meet Rome III criteria for IBS as determined by a
pediatric gastroenterologist.
Exclusion Criteria:
- Other pain-related diseases, functional gastrointestinal disorders, or somatization
disorder
- Mental retardation or pervasive developmental disorder or epilepsy
- Psychosis
- Genetic or chromosomal disorders
- Currently receiving psychoactive drug treatment
- Patients with pacemakers, metal clips used in previous surgery or other device which
are not compatible with MRI scanning
- Inability to lie still in the scanner
- Claustrophobia (Inability to lie still in the scanner)
- Pregnancy
- Subjects who admit to substance abuse during screening
- Orthodontic braces
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