The Effect of Low Intensity Exercise on Quality of Life and Hemodynamics in Patients With Permanent Atrial Fibrillation

1. Twelve patients will be enrolled. Each subject will first serve as their own control and
then serve in the treatment group. Subjects will be required to sign informed consent
prior to any study procedure.

2. The exercise program will be structured as follows:

At the time of enrollment, patients will undergo an exercise treadmill test to measure
cardiac hemodynamics, including VO2max (measured non-invasively using gas exchange) and
maximal heart rate. Average heart rate over 24 hours will also be measured by a 24-hour
Holter monitor before and after the exercise program. The maximal exercise testing will
be performed on a treadmill using an incremental protocol based on the estimated fitness
level established during a warm up.

For the first 8-weeks of their participation, patients will act as their own control and
not exercise. When the 8 week period is complete, they will return for another exercise
treadmill test and 24-hour Holter monitor.

For the second 8-weeks of their participation, patients will participate in exercise
training. The initial 2 weeks of exercise will be supervised at the St. Paul University
Hospital exercise facility for twenty minutes a day, four times a week. Exercise will be
done by walking or use of aerobic exercise equipment, which include a treadmill,
elliptical machine, cycle ergometer or rowing machine according to patient preference
and availability of exercise facilities at home.

During this period the patients will commence training at an intermediate effort based
on perceived exertion (Borg Scale 11-13). The intensity will be gradually increased to a
level corresponding to 70-75% VO2max or 15 on the Borg Scale, whichever represents the
least effort.

For the remaining six weeks, the patients will continue the exercise program at the
perceived intensity learned during the first two weeks of training. During these six
weeks, the patients will be asked to exercise for 30 minutes, five times per week.

Participants can exercise at home if they wish, but they will be required to undergo
supervised exercise at least once per week during this six week period and will be
required to keep an exercise log for monitoring their unsupervised efforts.

At the end of this 8-week program of exercise training, patients will return for a third
exercise treadmill test and 24-hour Holter monitor.

3. The Quality of Life survey will be assessed with two forms, the Short Form 36 (SF 36)
and the Arrhythmia Related Symptom Severity Check List (SSCL). Patients will be asked to
fill out both the SF 36 QOL and SSCL QOL survey and submit to a Physical Activity Recall
(PAR) interview each time they have the exercise treadmill test and 24-hour Holter.

Inclusion Criteria:

1. Patients with permanent atrial fibrillation for at least three months duration, on
stable medical therapy and in whom no additional interventions are planned to treat AF
either due to clinical reasons or patient preferences

2. Have the ability to understand and sign consent to participate and be willing and able
to comply with prescribed exercise and schedule of evaluations

3. Sedentary lifestyle as determined by Physical Activity Recall (PAR)

4. Be greater than 18 years of age

Exclusion Criteria:

1. Inability to exercise

2. Functional Class IV CHF symptoms

3. Active symptoms of angina, coronary artery disease

4. Patient with recent history of myocardial infarction

5. Patient with moderate or severely depressed left ventricular function (LVEF < 40 %)

6. Patient with any significant co-morbidities that may limit ability to exercise

7. Patients already engaged a structured exercise program