Safety of Vitamin D Supplementation in Older Persons
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 65 - 95 |
| Updated: | 4/21/2016 |
| Start Date: | April 2008 |
| End Date: | April 2009 |
Safety of Vitamin D Supplementation in the Elderly
This study will evaluate the safety over 6 months of two different doses of vitamin D
(cholecalciferol) in men and women age 65 and older. It will also evaluate if
supplementation with vitamin D improves physical performance.
(cholecalciferol) in men and women age 65 and older. It will also evaluate if
supplementation with vitamin D improves physical performance.
120 ambulatory men and women ages 65 to 95 will be enrolled in this study. Each subject will
participate in the clinical trial for 6 months.
Parathyroid hormone, vitamin D, and serum and urinary calcium will be measured periodically.
Physical performance will be tested at baseline and throughout the study.
participate in the clinical trial for 6 months.
Parathyroid hormone, vitamin D, and serum and urinary calcium will be measured periodically.
Physical performance will be tested at baseline and throughout the study.
Inclusion Criteria:
- ambulatory
Exclusion Criteria:
- hypercalcemia
- hypercalciuria > 4 mg/kg body weight/day
- primary, secondary, or tertiary hyperparathyroidism
- renal insufficiency (serum creatinine > 2 mg/dL )
- history of nephrolithiasis
- treatment with vitamin D (ergocalciferol, cholecalciferol, calcitriol)
- treatment with anticonvulsants
- Paget's disease
- severe cardiac, pulmonary, hepatic, renal, or neurological disease
- life expectancy < 1 year
- participation in another trial
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University of Miami A private research university with more than 15,000 students from around the...
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