Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS)
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies, Endocrine |
| Therapuetic Areas: | Endocrinology, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 10/21/2012 |
| Start Date: | November 2005 |
| End Date: | March 2009 |
| Contact: | Paulina A Essah, MD |
| Email: | pessah@mcvh-vcu.edu |
| Phone: | 804-828-9697 |
Combination Metformin and Oral Contraception for PCOS
The purpose of this research study is to determine if adding Metformin, a drug that reduces
insulin resistance, to birth control pills will reduce the risk of developing type 2
diabetes, high blood pressure. high lipid levels and heart disease in women with PCOS
Inclusion criteria: PCOS women between the ages of 18-45,< 8 periods annually, elevated
serum free testosterone, normal thyroid function tests and serum prolactin, exclusion of
late onset adrenal hyperplasia, acceptable health based on interview and medical history,
physical exam and lab tests, ability to comply with the requirements of the study and to
provide signed, witnessed informed consent.
Inclusion Criteria:
- Ages 18-45, , 8 menstrual cycles annually, elevated serum free testosterone, normal
thyroid function test and serum prolactin, exclusion of late onset adrenal
hyperplasia
Exclusion Criteria:
- Diabetes mellitus, pulmonary, cardiac, renal, hepatic, cholestatic, neurologic,
psychiatric, infectious, malignant diseases,history of breast cancer, history of DVT,
pregnancy and lactation.
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