T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignancies
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Lymphoma, Anemia, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | Any - 100 |
| Updated: | 4/21/2016 |
| Start Date: | November 2001 |
| End Date: | December 2014 |
Objectives:
1. To evaluate disease free survival after Campath 1H-based in vivo T-cell depletion and
non-myelo-ablative ablative stem cell transplantation in patients with hematologic
malignancies.
2. To evaluate the incidence and severity of acute and chronic GVHD after Campath 1H-based
in vivo T-cell depletion, in patients with hematologic malignancies undergoing
non-myelo-ablative stem cell transplantation.
3. To evaluate engraftment and chimerism after Campath 1H-based in vivo T-cell depletion
and non-myelo-ablative ablative stem cell transplantation in patients with hematologic
malignancies.
1. To evaluate disease free survival after Campath 1H-based in vivo T-cell depletion and
non-myelo-ablative ablative stem cell transplantation in patients with hematologic
malignancies.
2. To evaluate the incidence and severity of acute and chronic GVHD after Campath 1H-based
in vivo T-cell depletion, in patients with hematologic malignancies undergoing
non-myelo-ablative stem cell transplantation.
3. To evaluate engraftment and chimerism after Campath 1H-based in vivo T-cell depletion
and non-myelo-ablative ablative stem cell transplantation in patients with hematologic
malignancies.
Inclusion Criteria:
- Zubrod performance status 2 (See Appendix B).
- Life expectancy is not severely limited by concomitant illness.
- Adequate cardiac and pulmonary function. Patients with decreased LVEF or PFTS will be
evaluated by cardiology or pulmonary prior to enrollment on this protocol.
- Serum creatinine <1.5 mg/dL or Creatinine Clearance >50 ml/min .
- Serum bilirubin 2.0 mg/dl, SGPT <3 x upper limit of normal
- No evidence of chronic active hepatitis or cirrhosis.
- HIV-negative
- Patient is not pregnant
- Patient or guardian able to sign informed consent.
Exclusion Criteria:
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