Genetics of Symptomatology and Treatment Response in Psychotic Major Depression

From the blood sample you donate, the researchers will obtain DNA. This DNA will be used to
search for DNA markers related to the underlying biology of psychiatric illness and how this
might explain the symptoms of these disorders. Research using DNA is an important way to try
to understand human disease and/or the role genes play in disease. In effect, part of your
blood sample will be used to attempt to understand how genetic factors contribute to the
symptoms of such psychiatric conditions as major depression.

Inclusion Criteria:

1. You are currently experiencing symptoms that are consistent with an episode of major
depression without symptoms of psychosis (such as hallucinations, delusions or
disorder of thought process), or

2. You are currently experiencing symptoms that are consistent with an episode of major
depression with symptoms of psychosis (such as hallucinations, delusions or disorder
of thought process), or

3. You have been diagnosed with either schizophrenia or schizoaffective disorder, or

4. You are a volunteer without a history of psychiatric illness (a healthy control
subject).