Washed Versus Standard Blood Cell Transfusions in Pediatric Open Heart Surgery
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | July 2008 |
| End Date: | November 2009 |
| Contact: | Jill Cholette, MD |
| Email: | Jill_Cholette@urmc.rochester.edu |
| Phone: | 585-275-0189 |
Standard vs. Washed Blood Cell Transfusions in Pediatric Cardiac Surgery: Impact on Post-operative Inflammation as Evidenced by the IL-6 to IL-10 Ratio.
Background: Children having open heart surgery to repair congenital heart defects
demonstrate a large inflammatory response to the heart-lung machine and to surgery itself.
In general, the more intense their inflammatory response, the more critically ill they are
following surgery. These children routinely require large numbers of blood transfusions
during and following surgery as part of their medical management that adds to their
heightened inflammatory state. Whether additional steps to "wash" blood products and remove
the substances contributing to post-transfusion inflammation will limit this response, and
improve the health of children following open heart surgery, remains to be studied.
Aims: To compare the inflammatory response in children having open heart surgery who
receive washed versus unwashed blood transfusions.
Methods: We will randomly assign children having open heart surgery to one of two groups:
group 1 will receive blood transfusions per the current standard of care, group 2 will
receive blood transfusions that have been washed in addition to the current standard of
care. We will then use blood tests to measure the inflammatory response in children of each
group. We will compare the results to determine whether washing blood transfusions
decreases inflammation and post-operative complications following open heart surgery.
Conclusion: We believe that washing blood transfusions given to children following open
heart surgery will decrease their inflammatory response and improve their overall health.
Inclusion Criteria:
1. age < 18 years
2. surgical repair at URMC by the pediatric cardiac surgical team
3. informed consent signed by the parent or legal guardian, and if applicable, assent
obtained from the subject.
Exclusion Criteria:
1. Age ≥18 years
2. inability to provide consent/assent; 3) subjects having "emergent" surgical
procedures. Subjects with chronic inflammatory or autoimmune disorders will not be
excluded
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