Clinical Evaluation of the Effect of Duodenal-Jejunal Bypass on Type 2 Diabetes

Inclusion Criteria:

- Adults age 20-65 years

- Clinical diagnosis of type II diabetes buy on of the following three criteria
(American Diabetes Association)

1. A normal or high C-peptide level (to exclude type 1 diabetes) (>.9ng/ml)

2. A random plasma glucose of 200mg/dl or more with typical symptom of diabetes

3. A fasting plasma glucose of 126mg/dl or more on more than one occasion

- BMI 22-34 KG/m2

- Patients on oral hypoglycemic medications or insulin to control T2DM

- Inadequate control of diabetes as defined as HbA1c>7.5

- No contraindication for surgery or General Anesthesia as determined by
multidisciplinary surgical team

- Ability to understand and describe the mechanism of action of ricks and benefits of
the operation

Exclusion Criteria:

- Patients who meet any of the following exclusion criteria will be exclusion criteria
will be excluded from enrollment into the study

- Enrolled in another clinical study which involves and investigational drug

- Diagnosis type 1 diabetes

- Pregnancy (all female patients will have beta HCG) or planned pregnancy within 2
years of entry into the study or unwilling to use reliable contraceptive method

- Previous gastric or esophageal surgery

- Immunosuppressive drugs including corticosteroids

- Coagulopathy (INR>1.5 or platelets<50,000/ul)

- Anemia (Hgb<10.0g/dl)