Screening for Subjects to Participate in Studies of Blood Disorders

This study allows the evaluation of subjects in order to determine their ability to safely
participate in other active NIH research studies studying blood disorders. This protocol
serves several purposes: 1) allows detailed investigations into the blood disorders of these
subjects, and the status of other organ systems that would determine their ability to safely
tolerate specific aspects of active research protocols; 2) allows investigators to offer
clinical diagnostic testing and procedures to patients if this treatment will facilitate
their participation in a clinical trial; 3) allows investigations as to whether a donor is
HLA matched, fit to receive G-CSF, and fit to undergo apheresis and therefore eligible to
participate as a donor on a bone marrow transplant protocol; 4) allows the evaluations of
healthy volunteers as to whether they are eligible for participation as control subjects on
protocols that require generally good health status by history or physical exam findings, or
laboratory assessments; and 5) allows for the collection and storage of research specimens
and samples obtainable by minimal risk for development or validation of novel clinical tools
and approaches to disease. After completion of the screening process, the subject will either
be offered a chance to participate in an active research protocol, or if no appropriate
protocol is identified, subjects with blood disorders will have recommendations for other
treatment options relayed to them and/or to the primary or referring physician.

- INCLUSION CRITERIA:

Subjects will be entered on this protocol at the time of their first visit to the NIH
Clinical Center outpatient clinic or inpatient service if the subject is able to give
consent/assent and the subject may have a blood disorder, may be a stem cell transplant
donor, or may be a healthy volunteer.

- The subject or the subject s guardian is capable of informed consent and willing to
sign the consent form after initial counseling by clinical staff. Additional consent
for clinically indicated procedures (central venous catheter placement; biopsy of
liver, kidney; or bone marrow) or blood transfusions will be obtained.

- The subject has a reasonable likelihood of having a disorder for which MMB or MCHB has
an active research protocol, and based on information received from an outside
physician, he/she appears to meet at least preliminary eligibility criteria for that
protocol.

- The subject has been identified as a potential donor for a subject for whom the MMB or
MCHB has an active stem cell transplant protocol and based on information received
from an outside physician, he/she appears to meet preliminary eligibility as a donor.

- The subject (age greater than or equal to18) is a healthy volunteer for whom the MMB
or MCHB has an active study recruiting healthy normal volunteers and he/she appears to
meet preliminary eligibility as a healthy volunteer.

EXCLUSION CRITERIA:

- Unable to comprehend the investigational nature of the protocol participation

- Abnormal CBC for healthy volunteers

- Positive pregnancy test for stem cell donors and healthy volunteers