Drug-Induced Sleep Endoscopy for Upper Airway Evaluation in Obstructive Sleep Apnea



Status:Recruiting
Conditions:Insomnia Sleep Studies, Pulmonary
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - Any
Updated:5/2/2018
Start Date:February 2004
End Date:June 2020
Contact:Eric J Kezirian, MD, MPH
Email:eric.kezirian@med.usc.edu

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Trial Summary
Trial Overview
Inclusion Criteria
Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate
the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study
has investigated the reliability of this technique, demonstrating moderate-substantial
interrater and test-retest reliability. This research has also compared DISE findings to
those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not
responded to previous sleep apnea surgery. These papers have been published and available
through PubMed. Additional research is ongoing, with examination of DISE findings, comparison
to other evaluation techniques, and the association between DISE findings and surgical
outcomes.


Inclusion Criteria:

- Adult patients with OSA considering surgical treatment

Exclusion Criteria:

- Minors

- Pregnant women

- Patients unable to provide informed consent in English themselves

- Prisoners

- Allergy to propofol, soybean oil, egg lecithin or glycerol

- Other contraindication to use of propofol (decision of anesthesiologist or
otolaryngologist.)
We found this trial at
2
sites
Keck Medical Center of USC
Los Angeles, California 90033
Phone: 323-442-5790
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University of Southern California, Dept. of Otolaryngology-Head & Neck Surgery
Los Angeles, California 90033
Principal Investigator: Eric Kezirian, MD, MPH
Phone: 323-442-5790
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Los Angeles, CA
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