Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy

Inclusion Criteria:

- Ages 21 and over

- Able to read and write in English

- Smoker

- Heavy drinker

Exclusion Criteria:

- Any significant current medical or psychiatric conditions that would contraindicate
the consumption of alcohol or nicotine

- Significant hepatocellular injury

- Positive test result at intake appointments on urine drug screens conducted for
opiates, cocaine, or benzodiazepines

- Women who are pregnant or nursing

- Suicidal, homicidal, or evidence of severe mental illness

- Prescription of any psychotropic drug in the 30 days prior to study enrollment

- Blood donation within the past 8 weeks

- Individuals who are seeking treatment for drinking or smoking who have attempted to
quit drinking or smoking within the past 3 months

- Specific exclusions for administration of nicotine nasal spray not specified above
including nasal polyps, chronic nasal congestion, allergies, sinusitis

- Specific exclusions for administration of nicotine patch not specified above including
history of dermatoses

- Reported sensitivity or allergies to pepper or pepper spray, peppermint, or prior
adverse reaction to nicotine spray

- Participation within the past 8 weeks in other studies that involve additive blood
sampling and/or interventional measures that would be considered excessive in
combination with the current study