Efficacy of Natural Vitamin E Tocotrienol on the Treatment of Surgical Scars
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cosmetic |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/31/2018 |
| Start Date: | July 2008 |
| End Date: | December 2019 |
The overall goal of this study is to determine the efficacy of tocotrienol (TCT), a natural
form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as
the basal levels of TCT in normal human skin and adipose tissue.
form of vitamin E, in preventing or reducing scar formation in human skin wounds as well as
the basal levels of TCT in normal human skin and adipose tissue.
Scar formation is the physiological and inevitable end point of mammalian wound healing and
there is substantial evidence that inflammation is an essential prerequisite for scarring.
Although scar tissue restores the normal skin barrier, the new tissue is inferior in
structural, aesthetic, and functional respects. The mammalian wound healing response may have
originated during the time of high susceptibility to infection. Therefore, we may have
developed speed optimized wound healing where a multiple redundant compensating rapid
inflammatory response allows the wound to heal quickly without infection. The scar is then
the price mammals have to pay for evolutionary survival after being wounded.
Tocotrienol may be an effective tool to prevent or reduce normal, hypertrophic, or keloid
scarring by mediating the inflammatory response. Tocotrienol is a safe and convenient
treatment that could be used by mouth or topically. There has never been a study on the
effectiveness of tocotrienol in preventing or reducing scar formation.
there is substantial evidence that inflammation is an essential prerequisite for scarring.
Although scar tissue restores the normal skin barrier, the new tissue is inferior in
structural, aesthetic, and functional respects. The mammalian wound healing response may have
originated during the time of high susceptibility to infection. Therefore, we may have
developed speed optimized wound healing where a multiple redundant compensating rapid
inflammatory response allows the wound to heal quickly without infection. The scar is then
the price mammals have to pay for evolutionary survival after being wounded.
Tocotrienol may be an effective tool to prevent or reduce normal, hypertrophic, or keloid
scarring by mediating the inflammatory response. Tocotrienol is a safe and convenient
treatment that could be used by mouth or topically. There has never been a study on the
effectiveness of tocotrienol in preventing or reducing scar formation.
Inclusion Criteria:
- 18 years of age or older.
- Non- smoker
- No current medications that alter liver metabolism (e.g., Phenobarbital, HmG co-A
inhibitors, etc.)
- Non- pregnant or non-breastfeeding
- No current use of dietary supplements containing vitamin-E
- Not actively abusing drugs or alcohol
Exclusion Criteria:
- Under 18 years of age
- Prisoners
- Current smoker
- Pregnant or breastfeeding
- HIV diagnosis
- Viral hepatitis diagnosis
- Immunosuppressive therapy
- Actively abusing drugs or alcohol
- Current use of dietary supplements containing vitamin-E
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Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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