Botulinum Toxin for Carpal Tunnel Syndrome

To compare local steroid injections to local Botulinum toxin A injection in a double-blinded
study. The goal is to investigate if Botulinum toxin A injections are effective for Carpal
Tunnel Syndrome compared to steroid injections in terms of pain relief and length of symptom
alleviation.

Inclusion Criteria:

- Any individual with symptoms of carpal tunnel syndrome and a diagnosis of CTS either
clinically or via EMG will be included into this study. There will be a total of 20
subjects displaying symptoms of CTS. The gender of the subjects will not determine
enrollment. There is no requirement of male to female ratio for this study. There is
no age cut-off or minimal age requirement to enroll in the study. No specific Racial
or ethnic restrictions will be present for this study. Female subjects of
childbearing potential (not surgically sterile or postmenopausal for at least 2
years) must have a negative pregnancy test at screening.

Exclusion Criteria:

1. Any individual who has a diagnosis of CTS (by EMG or other means) but no symptoms of
CTS will be excluded from this study.

2. Vulnerable subjects as defined as children, pregnant women, those with limited
autonomy, decisional incapacity and prisoners will not be enrolled in this study.

3. Individuals with any history of carpal tunnel release surgery and recurrent or
persistent symptoms will be excluded form this study.

4. Subject is pregnant or lactating.