Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition
| Status: | Terminated |
|---|---|
| Conditions: | Cognitive Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 12/23/2017 |
| Start Date: | February 2008 |
| End Date: | March 2017 |
The purpose of this study is to evaluate whether or not cerebral atrophy scores obtained from
a brain MRI can correlate with Cognitive Test results. These results hope to demonstrate a
link between cerebral ischemic/degenerative changes shown on the MRI and cognition functions
results.
a brain MRI can correlate with Cognitive Test results. These results hope to demonstrate a
link between cerebral ischemic/degenerative changes shown on the MRI and cognition functions
results.
Preliminary evidence indicates that intracranial atherosclerosis may predict incident
cerebrovascular events and central atrophy. Age induced changes on cerebral tissue in
adulthood is witnessed as atrophy and well know ischemic changes on imaging studies. There is
no consensus at this time what constitutes normal, age induced atrophy and pathologic atrophy
on imaging studies. The same challenge is also encountered for ischemic cerebral parenchymal
change.
Until recently there have been several important limitations in this research 1) Measurement
of cerebral tissue loss and amount of ischemic insult was based on a qualitative grading (2)
There was no cognitive testing. With Advancements in software technology that have now
allowed for measurements of CSF and brain volumes in reliable and reproducible ways and the
neuroradiologist having access to the subject's Neurological Cognitive Testing Scores, this
study will objectively measure MRI findings and correlate them with the level of cognitive
function.
This study will look at subjects who have undergone cognitive testing from the Neurology
Clinic and then referred for an MRI brain exam, as standard of care testing. The MRI
information will be acquired by volumetric technique for calculation of brain and CSF volumes
and MRI data will be plotted against the cognitive test results.
The results of this study will be to correlate quantitative measures of cerebral atrophic and
ischemic changes with level of cognition and to establish reliable imaging criteria that can
help identify normal, age induced versus pathologic. Information obtained will shed light to
cognitive effects and imaging appearance of: Separation of normal age related changes from
pathologic states, changes leading to dementia and normal pressure hydrocephalus.
cerebrovascular events and central atrophy. Age induced changes on cerebral tissue in
adulthood is witnessed as atrophy and well know ischemic changes on imaging studies. There is
no consensus at this time what constitutes normal, age induced atrophy and pathologic atrophy
on imaging studies. The same challenge is also encountered for ischemic cerebral parenchymal
change.
Until recently there have been several important limitations in this research 1) Measurement
of cerebral tissue loss and amount of ischemic insult was based on a qualitative grading (2)
There was no cognitive testing. With Advancements in software technology that have now
allowed for measurements of CSF and brain volumes in reliable and reproducible ways and the
neuroradiologist having access to the subject's Neurological Cognitive Testing Scores, this
study will objectively measure MRI findings and correlate them with the level of cognitive
function.
This study will look at subjects who have undergone cognitive testing from the Neurology
Clinic and then referred for an MRI brain exam, as standard of care testing. The MRI
information will be acquired by volumetric technique for calculation of brain and CSF volumes
and MRI data will be plotted against the cognitive test results.
The results of this study will be to correlate quantitative measures of cerebral atrophic and
ischemic changes with level of cognition and to establish reliable imaging criteria that can
help identify normal, age induced versus pathologic. Information obtained will shed light to
cognitive effects and imaging appearance of: Separation of normal age related changes from
pathologic states, changes leading to dementia and normal pressure hydrocephalus.
Inclusion Criteria:
- Subjects older than 50 years of age
- Subjects who have undergone Cognitive Testing
- Subjects who can cooperate and give informed consent
Exclusion Criteria:
- Subjects with known medical conditions predisposing them for atrophy such as: Chronic
renal failure, HIV, head/neck tumors, prior radiation, post- traumatic brain disorder,
metabolic disorders of brain, polysubstance abuse, and steroid use
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