Long-Term Data Collection From Participants in Adult AIDS Clinical Trials

A compilation of outcomes of various antiretroviral therapies would be beneficial when
evaluating which strategies are most effective in long-term treatment of HIV-1. Using data
from present and recently completed studies, this study will collect information on
therapies and their control of HIV infection and maintenance of durable suppression of HIV-1
replication.

No treatment is provided by this study, but patients will continue to receive highly active
antiretroviral therapy (HAART) from other studies in which they are coenrolled. Blood and
urine collection will occur at study entry and periodically throughout the study. Women may
undergo pelvic exams and Pap smears. Portions of blood samples will be stored to evaluate
genotypic/phenotypic susceptibility testing. Medical histories, physical exams, and
questionnaires will be completed periodically.

Inclusion Criteria

- HIV-1 infected

- Enrolled in an AIDS Clinical Trial Group (ACTG) parent study and has enrolled in this
study on or before the Week 16 visit of the parent study, including the visit window
of the parent study. More information on this criterion can be found in the protocol.

- Willing to provide consent for the release and use of clinical data from the parent
study

- Life expectancy of at least 24 weeks

- Parent or guardian willing to provide informed consent, if applicable

Exclusion Criteria

- Active alcohol or drug abuse that may interfere with the study