Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors
| Status: | Completed |
|---|---|
| Conditions: | Lymphoma, Neurology |
| Therapuetic Areas: | Neurology, Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/23/2012 |
| Start Date: | July 2008 |
| End Date: | December 2013 |
| Contact: | Edward A Neuwelt, MD |
| Email: | neuwelte@ohsu.edu |
| Phone: | 503-494-5626 |
Neurotoxicity in Primary Central Nervous System Lymphoma: An International, Collaborative, Observational Study of Cognition in Long-Term Survivors
This research is being done to investigate cognition in long term survivors of Primary
Central Nervous System Lymphoma (PCNSL). Sometimes caregivers as well as patients who no
longer have the disease report cognitive problems such as reduced memory or attentional
dysfunction and decreased quality of life. Unfortunately, little is known about what may
contribute to this cognitive dysfunction in part because PCNSL is a rare disease and
sensitive tests have not often been used in the research studies. This project is being
conducted to help understand what factors, such as radiation, may contribute to cognitive
dysfunction and better define the relationship between brain structure and thinking in
people who have had PCNSL.
This is an international, multi-center project that will enroll as many as 118 subjects of
which approximately 35 will be enrolled at OHSU. Neuropsychological testing will consist of
a battery of paper and pencil tests that examine abilities such as memory, motor skills,
attention and speed of information processing. Questionnaires that assess quality of life
will also be administered. These noninvasive tests are administered by a trained examiner
or neuropsychologist and last about 30 minutes. Subjects will also undergo an MRI of the
head which provides a picture of the brain's structure by placing an individual inside a
powerful magnet. Statistical analyses will examine the relationship between the
neuropsychological test scores and MR images as well as examine the contribution of factors
such as radiation, age, surgery, chemotherapy etc. to cognition.
Inclusion Criteria:
- Radiological and histological diagnosis of PCNSL
- Age 18 years or older
- Survived 2 years or more following treatment
- Able to complete neuropsychological and neuroimaging parts of the study
- Signed a written informed consent in accordance with institutional guidelines
Exclusion Criteria:
- Subject has experienced recurrent disease
- Subject has a contraindication for MRI
- Subject has a contraindication for neuropsychological testing
- Subject has stage IV or V renal insufficiency
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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