Evaluation of Human Brain Tumor Therapy Response by Magnetic Resonance (MR)

The purpose of this study is to see if new MRI methods which measure information related to
water, blood flow, and chemical makeup in the brain, can give early information of how well
treatment is working in patients with brain tumors.

Inclusion Criteria:

- Patients over the age of 18 who have been diagnosed with a brain tumor of the central
nervous system and a treatment plan has been discussed.

- Must be willing/able to undergo 3-5 MRI scans with IV contrast.

- You can take part in this study if you are NOT afraid of small, enclosed places.

Exclusion Criteria:

- A patient who is claustrophobic.

- Females who are pregnant or lactating.

- Patients who have electrically, magnetically or mechanically activated implants such
as heart pacemaker, magnetic surgical clips, prosthesis or or implanted neurological
stimulator.

- Any patient who has a history of allergic reactions to MR contrast agent (Omniscan,
Magnevist, MultiHance)

- Patients who require general anesthesia to complete MRI exam or patients who have had
a negative reaction to MRI sedation. (Chloral Hydrate, Pentobarbital or Versed)

- You should NOT have any metals, or implanted devices in your body (such as aneurysm
clips, pacemakers, or artificial joints or limbs.). You will need to tell us about
your medical history including any surgeries you have had.

Also, if your job or any other experience might have left metal fragments in your body,
please let us know, as the MRI has a strong magnetic field could move a metal fragment in
your body or interfere with an implanted device, such as a pacemaker, causing you harm.