Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease

COPD is a disease in which the lung airways are damaged and partly obstructed, making it
difficult to breathe. There is no cure for this disease, and it is the fourth leading cause
of death in the United States. Symptoms include coughing, excess mucus production, shortness
of breath, wheezing, and chest tightness. The most common risk factor for developing COPD is
cigarette smoking; however, only 15% to 20% of smokers are diagnosed with COPD in their
lifetimes, suggesting that some smokers are more prone to developing COPD than others.
Elastin, a protein found in the tissues surrounding the lung airways and in the alveolar
walls of the lung, is essential for healthy lung function. As elastin breaks down, lung
damage can occur, potentially leading to COPD. It is thought that some people may be
genetically predisposed to elastin damage by cigarette smoke, thus accounting for the select
group of smokers affected by COPD. This study will examine the ways in which elastin defects
contribute to the development of COPD. Researchers will examine whether genetic variations
play a role in altering elastin function and in influencing health outcomes in people with
COPD.

This study will enroll people with COPD that was caused by emphysema. Participants will
complete one study visit that will include a medical record and history review and blood
collection (or saliva collection, if blood draw is unsuccessful). A portion of blood will be
stored for future genetic research. Participants will also complete questionnaires to collect
information on activities, health, and quality of life. Study researchers will contact
participants at the end of the study to collect follow-up medical information.

Inclusion Criteria:

- Age equal to or greater than 18 years

- Ability to read and write in English

- Able to participate in the informed consent process

- Acceptable pulmonary function tests (PFTs) done at Barnes-Jewish Hospital within 1
month of study enrollment

- Relatively stable clinical status (not experiencing COPD exacerbation in the previous
6 weeks)

- Global Initiative for Chronic Obstructive Lung Disease (GOLD) class III or IV COPD
(FEV1/FVC less than 70% and FEV1 less than 50% of predicted value)

Exclusion Criteria:

- Pregnant

- Prisoner

- Vulnerable populations

- Pi Z phenotype (i.e., alpha-1 antitrypsin deficiency)

- Significant lung disease, other than COPD / emphysema / chronic bronchitis (e.g.,
interstitial lung disease, asthma or other predominant airway disease, cystic
fibrosis, active tuberculosis)

- Known active hepatitis B, hepatitis C, or HIV/AIDS (found in medical record review;
not prospectively evaluated)

- Coexisting active chronic inflammatory or collagen vascular disease, immunodeficiency
of any kind, non-cutaneous malignancy (melanoma is an exclusion), or previous organ
transplant