Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-Disease
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Blood Cancer, Orthopedic, Hematology |
| Therapuetic Areas: | Hematology, Oncology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/6/2019 |
| Start Date: | February 2, 1999 |
| End Date: | March 2, 2018 |
Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease
Blood contains different kinds of cells, white blood cells, red blood cells, and platelets.
In order to treat certain diseases, specific cell types can be removed from blood and
transplanted into patients. The process of removing white blood cells for the treatment of
leukemia is called apheresis.
This study will make available blood cell collections from volunteers genetically matched to
various degrees with recipients in order to test and, if necessary, refine the process of
removing white blood cell T-lymphocytes.
In order to treat certain diseases, specific cell types can be removed from blood and
transplanted into patients. The process of removing white blood cells for the treatment of
leukemia is called apheresis.
This study will make available blood cell collections from volunteers genetically matched to
various degrees with recipients in order to test and, if necessary, refine the process of
removing white blood cell T-lymphocytes.
This protocol has been written to make available apheresis collections from volunteers
matched to various degrees with recipients in order to test and, if necessary refine, the
selective immunodepletion procedure prior to introducing it in a clinical trial.
matched to various degrees with recipients in order to test and, if necessary refine, the
selective immunodepletion procedure prior to introducing it in a clinical trial.
- INCLUSION CRITERIA:
Family members of patients admitted to NHLBI allogeneic BMT protocols.
Ages 18 and older and less than age 65.
Parent of patient (obligate haplotype match) OR HLA 3/6, 4/6, 5/6, or 6/6 match with
patient.
Research apheresis available from patient.
EXCLUSION CRITERIA:
Pregnancy or lactation.
HLA type unknown.
More than one haplotype mismatch with patient.
History of any immunosuppressive disease.
History of chronic viral antigenic stimulus.
Venous access inadequate.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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