Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines

The purpose of this study is to determine if there are genetic variations that can explain a
genetic basis for cyclic vomiting syndrome (CVS), various phenotypes of CVS (e.g. menstrual,
Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic
migraine). This information will allow physicians to improve care for patients who have been
diagnosed with this disease and to provide their parents with more complete information
regarding the cause of this disease. This research is being done because many unanswered
questions remain regarding children with CVS.

Inclusion Criteria:

- Subjects age 0-21 years old with CVS (different phenotypes). Each patient's authorized
legal guardian must understand the nature of the study and must provide written
informed consent.

Exclusion Criteria:

- Subjects age > 22 years old Vomiting is not due to CVS or other related condition