Multiple Ascending Dose (MDX1105-01)
| Status: | Completed |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2009 |
| End Date: | July 2015 |
A Phase 1, Multidose Study of BMS-936559 (MDX-1105) Administered Every 14 Days in Subjects With Selected Advanced or Recurrent Solid Tumors
Collection of survival data, evaluation of PDL-1 expression in tumors, and evaluation of
PD-L1 receptor occupancy in peripheral blood has been added.
PD-L1 receptor occupancy in peripheral blood has been added.
This is an open label, multicenter, dose escalation and multidose study of MDX-11-5, a fully
human monoclonal IgG4 antibody targeting the Programed Death-Ligand 1 (PD-L1).
The study will consist of 3 periods: Screening (up to 28 days), Treatment (up to 16 six-week
cycles), and Follow-up (up to 6 months).
human monoclonal IgG4 antibody targeting the Programed Death-Ligand 1 (PD-L1).
The study will consist of 3 periods: Screening (up to 28 days), Treatment (up to 16 six-week
cycles), and Follow-up (up to 6 months).
Inclusion Criteria:
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 1
- The malignancies include relapsed/refractory renal cell carcinoma, non-small cell
lung cancer, colorectal adenocarcinoma, malignant melanoma, advanced/metastatic
epithelial ovarian cancer, gastric cancer, pancreatic cancer and breastcancer
- Must have measurable disease
Exclusion Criteria:
- Prior therapy with an anti-PD 1, anti-PDL 1, or anti-Cytotoxic T-Lymphocyte Antigen 4
antibody (or any other agents that target T-cell co-stimulation)
We found this trial at
11
sites
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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University of Chicago One of the world's premier academic and research institutions, the University of...
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Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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