Conjugated Hyperbilirubinemia and Pulse Oximetry
| Status: | Recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | August 2008 |
| Contact: | Elizabeth Ferry, RN |
| Email: | elizabeth.ferry@emoryhealthcare.org |
| Phone: | 404-712-1816 |
The Influence of Conjugated Hyperbilirubinemia on Pulse Oximetric Accuracy in Liver Disease
The purpose of this study is to determine if higher levels of bilirubin in the blood of
people with liver disease affects how accurate a pulse oximeter machine is able to measure
the concentration of oxygen in the blood. Previous studies have reported conflicting results
regarding the affect of high levels of bilirubin in the blood on the accuracy of the pulse
oximeter reading. Initial studies showed an underestimation of the oxygen concentration in
the presence of elevated bilirubin. Subsequent studies have suggested that high levels of
bilirubin in the blood do not influence the accuracy of the pulse oximeter machine. However,
recent reports in bone marrow transplant literature and our personal observations in
patients with liver disease suggest that high bilirubin levels are associated with an
overestimation of the oxygen concentration as measured by the pulse oximeter machine.
Inclusion Criteria:
- Patients with established liver disease or dysfunction, as determined by abnormal
liver function tests, imaging, or biopsy
Exclusion Criteria:
- Patients with unconjugated hyperbilirubinemia, which could be associated with
elevations in carboxyhemoglobin
- Patients with poor peripheral perfusion that would compromise accurate pulse
oximetric determination
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