Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).

Background:

There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress
disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as
those in the general population. In addition, alcohol dependence is the most common comorbid
condition in men with PTSD. Despite this, little is known about how to best treat
individuals with comorbid AD and PTSD. The use of an alpha-1 adrenergic receptor antagonist
represents a novel approach to treatment that may target symptoms of both AD and PTSD. There
is evidence of common neurobiological mechanisms that underlie both AD and PTSD. Prazosin is
an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment
of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol
dependence.

Objective:

The objective of this study is to evaluate the efficacy of prazosin (16mg) versus placebo in
reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD
and PTSD. Methods: Thirty participants with a current diagnosis of AD and PTSD will be
enrolled in a 13-week trial. They will be assigned, in a double-blind fashion, to either
prazosin or placebo. Significance: This project will be the first to compare prazosin to
placebo as effective treatments for reducing alcohol consumption and PTSD symptoms in
patients with both AD and PTSD.

Inclusion Criteria:

1. Males and females between the ages of 21-65 years old.

2. Current alcohol dependence, as determined by a structured clinical interview
(Structured Clinical Interview for DSM-IV Axis I Disorders) (SCID) (First et al.
1996).

3. Current PTSD as determined by the Clinician Administered PTSD Scale for DSM-IV(CAPS)
(Blake et al. 1995).

4. Patients with current alcohol dependence, with at least one recent episode of heavy
drinking (defined as 5 or more drinks per drinking episode) over the past 14 days.

5. Medically and neurologically healthy on the basis of history, physical examination,
EKG, screening laboratories (CBC w/ differential, TSH, Free-T4, ASAT, ALAT, GGT, BUN,
creatinine, calcium, phosphorous, magnesium, total protein, albumin, electrolytes,
VDRL, urinalysis, beta-HCG).

6. For women, negative pregnancy test and use of acceptable method of contraception.

Exclusion Criteria:

1. Females who are pregnant or lactating.

2. Individuals with a current unstable medical condition such as neurological,
cardiovascular, endocrine, renal, liver, or thyroid pathology (LFT 5 times normal,
abnormal BUN and creatinine, and unmanaged hypertension with BP more than 200/120)
which in the opinion of the physician would preclude the patient from fully
cooperating or be of potential harm during the course of the study.

3. Patients who meet current SCID criteria for the following major Axis I diagnoses
(Bipolar Disorders, Schizophrenia and Schizophrenia-type Disorders).

4. History of substance dependence (other than alcohol, cocaine, tobacco or cannabis) by
DSM-IV criteria in the last 30 days.

5. Individuals taking mood stabilizers and antipsychotic medications.

6. Individuals with a history of sensitivity to quinazolines or prazosin.

7. Individuals taking medications thought to influence alcohol consumption (naltrexone,
disulfiram, acamprosate).

8. Individuals taking adrenergic medication (e.g. clonidine).

9. Agents that may interact with prazosin such as drugs with CNS depressant effects
including tizanidine and xyrem.