The Pathophysiology of Orthostatic Hypotension
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 12 - 70 |
| Updated: | 1/12/2019 |
| Start Date: | December 1996 |
| End Date: | December 2020 |
The purpose of this study is to determine the cause of low blood pressure in selective
patients who have problems with their involuntary (autonomic) nervous system. These patients
frequently have had symptoms throughout their life, and their disorder might have a genetic
basis. The biochemical, physiological and pharmacological procedures in this study should
help us define the problem and perhaps lead to more effective treatment.
patients who have problems with their involuntary (autonomic) nervous system. These patients
frequently have had symptoms throughout their life, and their disorder might have a genetic
basis. The biochemical, physiological and pharmacological procedures in this study should
help us define the problem and perhaps lead to more effective treatment.
Inclusion Criteria:
- severe orthostatic hypotension and other autonomic symptoms but do not meet criteria
for standard diagnosis
- non-smokers
- drug-free
- able to give informed consent
- free of pulmonary, renal, hematopoietic, hepatic and cardiac disease
Exclusion Criteria:
- medications affecting the autonomic nervous system
- any chronic illness
- anemia (Hct<30)
- women of childbearing age who are pregnant or nursing
- smokers
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