Merits of Performing a Modified Template Retroperitoneal Lymph Node Dissection
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | September 2008 |
| End Date: | December 2013 |
Merits of Performing a Modified Template Retroperitoneal Lymph Node Dissection at Time of Nephroureterectomy for Urothelial Carcinoma of the Upper Urinary Tract
The Purpose of This Study:
In case of urothelial carcinoma of the upper urinary tract (a cancer originating from the
inner lining of the urinary tract) requiring the removal of the kidney, ureter, and cuff of
bladder (a surgical termed a nephroureterectomy). Previous studies in urothelial carcinoma
of the bladder, have shown that doing a lymph node dissection (surgically removing the lymph
nodes) may improve survival, or at least give an idea of what patients may need chemotherapy
(drugs to control the cancer cells that are outside the kidney-ureter) earlier (before the
nodes are enlarged in the imaging studies).
Participants will have a nephroureterectomy (taking the kidney and the ureter). We will also
be doing a lymph node dissection (taking the patient's lymph nodes in the same side of the
kidney) to look for malignancy outside of the kidney and ureter. The lymph nodes will be
sent to pathology for review.
Study visits will be scheduled 10 to 14 days after surgery for removal of stitches and
analysis of the patient's pathology report.
The following procedures will be done:
- History and physical examination, urinary cytology (test to look for malignant cells in
the urine) and surveillance cystoscopy (procedure to look inside the urethra and
bladder which is performed in the office under local anesthesia) every 3 months for the
first two years after treatment, every 6 months for the next two years and yearly
thereafter if the patient is free from recurrence.
- Radiographic studies including chest x-ray and abdomino-pelvic CT (CAT scans) will be
performed every 6 months for the first two years and then yearly thereafter.
- Bone scan (special imaging study to look for cancer spread in bone) in case of bone
pain or elevated alkaline phosphatase level.
After surgery patients will be followed every 3 months for the first 2 years after
treatment, every 6 months for the next two years and yearly thereafter if they are free from
recurrence.
We found this trial at
1
site
12902 USF Magnolia Dr
Tampa, Florida 33612
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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