Long-term Behavior Change - 1



Status:Completed
Conditions:Healthy Studies, Psychiatric
Therapuetic Areas:Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - 65
Updated:4/21/2016
Start Date:December 2004
End Date:June 2008

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Behavior Change: Reinforcement Schedule Effects

The purpose of this study is to determine if different reinforcement procedures (i.e.,
schedules) produce different patterns of long-term abstinence from methamphetamine. We
anticipate that the three contingency management conditions will promote longer periods of
abstinence in the year following treatment relative to the standard control group.
Furthermore, we predict that the intermittent reinforcement procedures will produce longer
periods of continued abstinence (i.e., long-term behavior change) in the year following
treatment than the continuous reinforcement procedure. Finally, we predict that the
intermittent unpredictable schedule will produce longer lasting behavior change than the
intermittent predictable schedule. Methamphetamine use will be measured using urine
toxicology and self-report of methamphetamine use.

Briefly the four study conditions are: (1) standard treatment which consists of 16 weeks of
psychosocial treatment, (2) continuous contingency management which consists of 16 weeks of
psychosocial treatment with a contingency management procedure in effect during the first
twelve weeks in which vouchers are made available after each provision of a
methamphetamine-negative urine test, (3) intermittent predictable contingency management
which consists of 16 weeks of psychosocial treatment with a contingency management procedure
in effect during the first twelve weeks in which vouchers are available after the provision
of every three consecutive methamphetamine-negative urine samples, and (4) intermittent
unpredictable contingency management which consists of 16 weeks of psychosocial treatment
with a contingency management procedure in effect during the first twelve weeks in which
vouchers are available on one day each week (randomly selected after the first week) for the
provision of methamphetamine-negative urine samples provided all urine samples since
delivery of the last reinforcer were also methamphetamine negative.

Inclusion Criteria:

- Meet Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for
methamphetamine dependence

- Willing and able to comply with study procedures

- Willing and able to provide written informed consent

Exclusion Criteria:

- Have a medical condition that, in the study Principal Investigator (PI's) judgment,
might interfere with safe study participation

- Have a recent (past 30 days) history of suicide attempts and/or current serious
suicidal intention or plan as assessed by the Beck Depression Inventory (BDI)

- Have a history of violent criminal behavior or be on parole

- Any other circumstances that, in the opinion of the PI, would interfere with safe
study participation
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Los Angeles, California 90025
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Rancho Cucamonga, California 91730
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