Vitamin D Deficiency and Low Bone Mineral Content in Children
| Status: | Archived |
|---|---|
| Conditions: | Obesity Weight Loss, Other Indications, Gastrointestinal |
| Therapuetic Areas: | Endocrinology, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | July 2008 |
| End Date: | June 2011 |
The Relationship Between Vitamin D Deficiency and Low Bone Mineral Content in Children
The Vitamin D study is designed to investigate the effect of body fat mass on vitamin D
levels in children. Earlier studies have shown that individuals with increased fat mass may
have low vitamin D levels.
Our specific hypothesis states that children with increased fat mass will have lower blood
levels of vitamin D when compared to non-obese children.Since vitamin D is the primary
hormone for bone mineralization in humans, low levels of vitamin D could lead to decreased
bone mineral content in these children.
Fifty prepubertal male and female children of ages between 3-12 years will participate in
this study. Of these, 25 obese children will be enrolled in the study group, and 25
non-obese children will serve as controls.
All subjects will fill out a comprehensive mineral intake questionnaire as part of the study
to ensure adequate calcium intake prior to the study.
All subjects will collect a first morning urine sample for calcium, creatinine, and NTX.
Fasting blood samples will be drawn for the following analytes: 25-hydroxyvitamin D, 1,
25-dihydroxyvitamin D, intact PTH, calcium, phosphorus, magnesium, osteocalcin, insulin,
c-peptide, fasting blood glucose, leptin, and adiponectin.
Bone Mineral Content will be evaluated in 16 obese subjects with vitamin D level of < 30
nmol/L.
We found this trial at
1
site
Umass Memorial Medical Center UMass Memorial Medical Center is the region's trusted academic medical center,...
Click here to add this to my saved trials
