Compromised Microcirculation in Women With Polycystic Ovary Syndrome



Status:Completed
Conditions:Ovarian Cancer, Women's Studies
Therapuetic Areas:Oncology, Reproductive
Healthy:No
Age Range:18 - 35
Updated:1/1/2014
Start Date:February 2008
End Date:December 2012
Contact:Nina Stachenfeld, PhD
Email:nstach@jbpierce.org
Phone:203 562-9901

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Trial Summary
Trial Overview
Inclusion Criteria
The scientific aims of the study are to determine how peripheral microcirculatory
responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local
heating and to determine the mechanism for testosterone effects on peripheral
microcirculatory responsiveness in women with PCOS.

In these studies, we propose to use the skin as a relatively non-invasive model to examine
cardiovascular and endothelial function in obese women with and without PCOS. Data have
indicated an important role for testosterone in influencing the peripheral microcirculation.
While testosterone can lead to vasodilation in the peripheral microcirculation in both men
and in women without PCOS, testosterone appears to induce vasoconstriction in women with
PCOS. The differential response between women with and without PCOS, and between men and
women may be the result of differential ET-1 actions in the vessel, and regulated by the
receptor subtype is involved in these actions.

Inclusion Criteria:

- Obese women (18-35) years with and without PCOS

Exclusion Criteria:

- Conditions that would preclude safe use of hormones
We found this trial at
1
site
John B. Pierce Laboratory
New Haven, Connecticut 06520
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mi
from
New Haven, CT
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