A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:Any
Updated:10/21/2012
Start Date:November 2008
End Date:November 2012
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

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Case Crossover Study of PDE5 Inhibitor Exposure as a Potential "Trigger Factor" for Acute NAION


The objective of this non-interventional study is to examine whether use of
Phosphodiesterase Inhibitors (PDE5s), including use of sildenafil, vardenafil, or tadalafil,
triggers the onset of acute NAION.


Sites will identify patients who meet the entry criteria during the conduct of their normal
practice. Patients meeting these criteria will be offered participation in the study after
reading and completing an informed consent document.

Inclusion Criteria:

- Male aged ≥45 years;

- Experienced abrupt visual change in only 1 eye

Exclusion Criteria:

- Pain determined by an ophthalmologist to be consistent with an inflammatory/arteritic
process or optic neuritis;

- History of NAION or optic neuritis.

- Participation in other studies within 60 days prior to entry in the study.
We found this trial at
32
sites
Houston, Texas 77030
1892
mi
from 98109
Houston, TX
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235 East 42nd Street
Clifton, New Jersey 07013
2402
mi
from 98109
Clifton, NJ
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Akron, Ohio 44314
2041
mi
from 98109
Akron, OH
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Alabaster, Alabama 35007
2091
mi
from 98109
Alabaster, AL
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Alliance, Nebraska 69301
1023
mi
from 98109
Alliance, NE
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Anchorage, Alaska 99501
1432
mi
from 98109
Anchorage, AK
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Anderson, South Carolina 29621
2227
mi
from 98109
Anderson, SC
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Arkansas City, Kansas 67005
1474
mi
from 98109
Arkansas City, KS
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Arvada, Colorado 80005
1010
mi
from 98109
Arvada, CO
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Asheville, North Carolina 28801
2187
mi
from 98109
Asheville, NC
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Ashland, Oregon 97520
377
mi
from 98109
Ashland, OR
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Atlanta, Georgia 30309
2177
mi
from 98109
Atlanta, GA
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Atlantis, Florida 33462
2698
mi
from 98109
Atlantis, FL
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Baltimore, Maryland 21234
2328
mi
from 98109
Baltimore, MD
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Bloomingdale, Illinois 60108
1710
mi
from 98109
Bloomingdale, IL
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Bossier City, Louisiana 71111
1820
mi
from 98109
Bossier City, LA
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Boston, Massachusetts 02115
2485
mi
from 98109
Boston, MA
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Bridgeport, Connecticut 06606
2424
mi
from 98109
Bridgeport, CT
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Burke, Virginia 22015
2314
mi
from 98109
Burke, VA
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Cape Girardeau, Missouri 63703
1801
mi
from 98109
Cape Girardeau, MO
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Cedar Rapids, Iowa 52401
1542
mi
from 98109
Cedar Rapids, IA
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Detroit, Michigan 48202
1930
mi
from 98109
Detroit, MI
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Duluth, Minnesota 55805
1411
mi
from 98109
Duluth, MN
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Fayetteville, Arkansas 72703
1643
mi
from 98109
Fayetteville, AR
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Incline Village, Nevada 89451
591
mi
from 98109
Incline Village, NV
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Lebanon, New Hampshire 03756
2392
mi
from 98109
Lebanon, NH
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Los Angeles, California 90027
979
mi
from 98109
Los Angeles, CA
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Pittsburgh, Pennsylvania 15212
2131
mi
from 98109
Pittsburgh, PA
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Rochester, New York 14642
2154
mi
from 98109
Rochester, NY
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Seattle, Washington 98166
12
mi
from 98109
Seattle, WA
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Washington, District of Columbia 20003
2322
mi
from 98109
Washington,
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West Jordan, Utah 84088
706
mi
from 98109
West Jordan, UT
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