Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)
| Status: | Terminated |
|---|---|
| Conditions: | Angina, Asthma, Chronic Obstructive Pulmonary Disease, Peripheral Vascular Disease, Cardiology, Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 40 - 85 |
| Updated: | 9/28/2018 |
| Start Date: | January 2009 |
| End Date: | March 2011 |
Comparison of Dobutamine and Regadenoson Stress CMR
The goal of this research is to determine the utility of Regadenoson (Lexiscan)for use as an
imaging agent with cardiac MR. If found useful, it will help us establish a protocol for
regadenoson stress MR perfusion (Regadenoson stress test with cardiac MR).The investigators
will compare regadenoson with dobutamine so each participant will undergo two studies. A
cardiac MR stress test with regadenoson and with dobutamine. The investigators participants
will include patients with history of COPD and Asthma, so it will also help us determine
feasibility of Regadenoson in these patient's subgroups.
imaging agent with cardiac MR. If found useful, it will help us establish a protocol for
regadenoson stress MR perfusion (Regadenoson stress test with cardiac MR).The investigators
will compare regadenoson with dobutamine so each participant will undergo two studies. A
cardiac MR stress test with regadenoson and with dobutamine. The investigators participants
will include patients with history of COPD and Asthma, so it will also help us determine
feasibility of Regadenoson in these patient's subgroups.
Inclusion Criteria:
- Men and women aged 40 to 85 years with OBSTRUCTIVE AIRWAY DISEASES (ASTHMA AND COPD)
and a forced expiratory volume (FEV1) > 0.5.
- Patients should have a clinical indication to undergo cardiac stress test with
dobutamine.
Exclusion Criteria:
- Those with pacemakers, defibrillators, functioning neural stimulator devices or other
implanted electronic devices.
- Ferromagnetic cerebral aneurism clips or other intraorbital and intracranial metal.
- An allergy to Gadolinium or other severe drug allergies.
- Acute myocardial infarction within 3 months.
- Moderate or severe aortic stenosis or other significant valvular disease;
- Claustrophobia.
- High grade (2o or 3o) AV Block.
- Closed angle glaucoma.
- Participants unable to provide informed consent.
- Renal dialysis (subjects with moderate-to-severe renal impairment defined as eGFR < 60
mL/min.
- A contraindication to receipt of dobutamine.
- Participants with known coronary artery disease will be included with the exception
that patients with left main or narrowings >50% in the distributions of the left
anterior descending, circumflex, and right coronary artery will be excluded.
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27103
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
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