Proton Radiation for Resectable Carcinoma of the Pancreas



Status:Active, not recruiting
Conditions:Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:11/19/2016
Start Date:February 2009
End Date:September 2040

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Trial Summary
Trial Overview
Inclusion Criteria

A Pilot Study Using Neoadjuvant Proton Beam Radiation Therapy and Chemotherapy for Marginally Resectable Carcinoma of the Pancreas

The purpose of this study is to find out what effects, good and/or bad, proton radiation
combined with chemotherapy and surgery has on you and your pancreatic cancer. This study
will look at the side effects from the treatment and the quality of your life in relation to
pain. It will also look at how the tumor responds to the combination of treatment with
radiation, chemotherapy and surgery.

Chemotherapy capecitabine on radiation days

Proton radiation over 6 weeks

Surgery 6 weeks after radiation completion

Adjuvant Chemotherapy starting 2-8 weeks after surgery with Gemzar

Inclusion Criteria:

- Pathologically confirmed adenocarcinoma of the pancreas.

- Patients must have marginally resectable disease.

- Patients with biliary obstruction must have adequate drainage prior to starting
chemoradiation.

Exclusion Criteria:

- Evidence of distant metastasis including peritoneal seeding and/or ascites.

- Previous irradiation to the abdomen that would compromise the ability to deliver the
prescribed treatment.

- Prior surgical resection.

- Gastroduodenal obstruction
We found this trial at
1
site
University of Florida Proton Therapy Institute
2015 Jefferson St
Jacksonville, Florida 32206
(904) 588-1800
Principal Investigator: Romaine C Nichols, MD
Phone: 877-686-6009
University of Florida Proton Therapy Institute When the University of Florida Proton Therapy Institute opened...
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mi
from
Jacksonville, FL
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