Viral & Host Factors Associated With Hepatitis B Virus-related Hepatocellular Carcinoma



Status:Terminated
Conditions:Liver Cancer, Cancer, Cancer, Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases, Oncology
Healthy:No
Age Range:18 - Any
Updated:6/30/2016
Start Date:March 2008
End Date:September 2013

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Trial Summary
Trial Overview
Inclusion Criteria

Viral and Host Factors Associated With Development of Hepatitis B Virus-related Hepatocellular Carcinoma

Adult liver cancer is the third leading cause of cancer deaths worldwide. The major risk
factor for liver cancer is hepatitis B virus (HBV) infection. The purpose of the study is to
sequence the HBV genome in patients with chronic HBV infection, and in patients with liver
cancer resulting from chronic HBV infection. The goal is to identify mutations in the HBV
genome that predisposes these high risk individuals to the development of liver cancer.


Inclusion Criteria:1. Patients diagnosed with liver cancer based on biopsy or serum AFP
level, associated with characteristic hypervascular liver tumors on triphasic spiral CT
scan or MRI.

2. Patients with non-cancer liver conditions such as cirrhosis, adenoma, cholangioma, or
nodular hyperplasia.

3. Patients with hepatitis B or hepatitis C viral infections not associated with liver
cancer.

Exclusion Criteria:No other patients except those listed above will be recruited.
Additionally, patients will be excluded if, upon looking through their medical records,
information required for data analysis are missing.
We found this trial at
1
site
Stanford University School of Medicine
291 Campus Dr
Stanford, California 94305
(650) 725-3900
Stanford University School of Medicine Vast in both its physical scale and its impact on...
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Stanford, CA
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