Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery



Status:Archived
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2008

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Trial Summary
Trial Overview
Inclusion Criteria

Phase II Trial of mTOR Inhibitor, Everolimus (RAD001), in Malignant Pleural Mesothelioma (MPM)


RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth.

PURPOSE: This phase II trial is studying how well everolimus works in treating patients with
pleural malignant mesothelioma that cannot be removed by surgery.


OBJECTIVES:

Primary

- To determine the 4-month progression-free survival in patients with unresectable
malignant pleural mesothelioma treated with everolimus.

Secondary

- To determine the response rate (confirmed and unconfirmed, complete and partial
responses) and disease control rate (response or stable disease) in patients with
measurable disease by RECIST and modified RECIST criteria.

- To determine overall survival of these patients.

- To evaluate the frequency and severity of toxicities associated with this treatment
regimen.

OUTLINE: This is a multicenter study.

Patients receive oral everolimus once daily on days 1-28. Courses repeat every 28 days in
the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed for 3 years.


We found this trial at
126
sites
Cancer Center of Kansas, PA - Newton
720 Medical Center Drive
Newton, Kansas 67114
(316) 282-0888
Cancer Center of Kansas, PA - Newton Dr. H.E. Hynes founded Cancer Center of Kansas,...
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University of New Mexico Cancer Center
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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Olympic Hematology and Oncology
2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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Bremerton, WA
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Presbyterian Cancer Center at Presbyterian Hospital
200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
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Charlotte, NC
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Hurley Medical Center
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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Flint, MI
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Northeast Georgia Heart Center, PC
Gainesville, Florida 30501
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Gainesville, FL
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Wayne Memorial Hospital, Incorporated
2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
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Skagit Valley Hospital Cancer Care Center
1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
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Harrison Poulsbo Hematology and Onocology
19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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University of California Davis Cancer Center
2279 45th Street
Sacramento, California 95817
(916) 734-5800
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
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Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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University Cancer Center at University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-4100
University Cancer Center at University of Washington Medical Center The Division of Radiation Oncology's work...
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Group Health Capitol Hill Campus
201 16th Avenue East
Seattle, Washington 98112
(206) 326-3000
Group Health Central Hospital Group Health Cooperative is a member-governed, nonprofit health care system that...
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Cancer Care Northwest - Spokane South
601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
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Wenatchee Valley Medical Center
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
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St. Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48706
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St. Joseph's Hospital
Ann Arbor, Michigan 48106
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CCOP - Michigan Cancer Research Consortium
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
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University of Michigan Comprehensive Cancer Center
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Mary Rutan Hospital
205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
Mary Rutan Hospital The hospital was endowed by the sale of a farm in Ridgeway...
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Billings Clinic - Downtown
801 N. 29th St
Billings, Montana 59107
406.238.2500
Billings Clinic - Downtown Based in Billings, Montana, Billings Clinic is a community-governed health care...
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St. Vincent Healthcare Cancer Care Services
1101 N 27th St # 201
Billings, Montana 59101
(406) 237-3585
St. Vincent Healthcare Cancer Care Services The Sisters of Charity of Leavenworth, Kansas, founded St....
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Montana Cancer Consortium CCOP
90 Poly Drive, Suite 2
Billings, Montana 59101
(406) 237-5460
Montana Cancer Consortium CCOP The Montana Cancer Consortium is a nonprofit organization whose mission is...
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University of Colorado, Boulder
Boulder, Colorado 80309
(303) 492-1411
University of Colorado, Boulder As the flagship university of the state of Colorado, CU-Boulder is...
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Bozeman Deaconess Cancer Center
931 Highland Blvd
Bozeman, Montana 59715
(406) 585-5070
Bozeman Deaconess Cancer Center Bozeman Deaconess Cancer Center provides the latest cancer technologies and treatment...
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Rocky Mountain Oncology
6501 E 2nd St
Casper, Wyoming 82609
(307) 235-5433
Rocky Mountain Oncology Rocky Mountain Oncology Center is a spacious, comfortable, state-of-the-art 19,000 square foot...
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Cancer Center of Kansas, PA - Chanute
505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Adena Regional Medical Center
272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Clackamas Radiation Oncology Center
9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
(503) 513-3300
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
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Grant Medical Center Cancer Care
111 S Grant Avenue
Columbus, Ohio 43215
(614) 566-4321
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Ohio Health Research Institute / Riverside Methodist Hospital
Columbus, Ohio 43214
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Doctors Hospital
5100 W Broad St
Columbus, Ohio 43228
(614) 544-1000
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Mount Carmel West Hospital
793 West State Street
Columbus, Ohio 43222
614-234-5000
Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
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Danville Regional Medical Center
142 S Main St
Danville, Virginia 24541
(434) 799-2100
Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
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David L. Rike Cancer Center at Miami Valley Hospital
1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
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Samaritan North Cancer Care Center
9000 North Main Street
Dayton, Ohio 45415
(937) 734-5800
Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
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Grandview Hospital
405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
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Good Samaritan Hospital - Dayton
2222 Philadelphia Dr
Dayton, Ohio 45406
(937) 734-2612
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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Dayton CCOP
3123 Research Boulevard Suite 150
Dayton, Ohio 45420
(937) 775-1350
Dayton CCOP We are a regional non-profit cancer research consortium serving the Miami Valley area...
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Oakwood Cancer Center at Oakwood Hospital and Medical Center
18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
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Decatur Memorial Hospital Cancer Care Institute
2300 N. Edward Street
Decatur, Illinois 62526
217-876-8121
Decatur Memorial Hospital Cancer Care Institute An American flag bearing only 48 stars waved above...
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Grady Memorial Hospital
561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
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Hematology-Oncolgy Associates of NNJ-PA
Denville, New Jersey 07834
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Wayne State University/Detroit Medical Center
4201 St Antoine St
Detroit, Michigan 48201
(313) 577-1429
Wayne State University/Detroit Medical Center Founded in 1868, the Wayne State University School of Medicine...
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Cancer Center of Kansas, PA - Dodge City
2020 Central Ave
Dodge City, Kansas 67801
(620) 227-2488
Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
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Shaw Regional Cancer Center
Edwards, Colorado 81632
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Cancer Center of Kansas, PA - El Dorado
700 West Central
El Dorado, Kansas 67042
(316) 889-0099
Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
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Blanchard Valley Medical Associates
200 West Pearl Street
Findlay, Ohio 45840
419-424-0380
Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
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Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas 66701
(620) 223-8589
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Middletown Regional Hospital
105 Mcknight Drive
Franklin, Ohio 45005
513-424-2111
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Valley View Hospital Cancer Center
Glenwood Springs, Colorado 81601
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Great Falls Clinic, Llp
Great Falls, Montana 59405
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Sletten Cancer Institute at Benefis Healthcare
1101 26th Street South
Great Falls, Montana 59405
406.455.5000
Sletten Cancer Institute at Benefis Healthcare Benefis Hospitals has 516 beds at its two campuses...
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Wayne Hospital
835 Sweitzer St
Greenville, Ohio 45331
(937) 548-1141
Wayne Hospital Stretching back to our roots nearly 100 years ago, Wayne HealthCare has always...
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Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
114 Woodland St, Hartford
Hartford, Connecticut 06105
(860) 714-4000
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center While better...
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Northern Montana Hospital
30 13th St
Havre, Montana 59501
(406) 265-2211
Northern Montana Hospital Northern Montana Hospital (NMH) is the center of a comprehensive system of...
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St. Peter's Hospital
2475 Broadway St
Helena, Montana 59601
(406) 442-2480
St. Peter's Hospital Welcome to St. Peter’s Hospital, providing premier health care to a five–county...
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Cancer Center of Kansas-Independence
800 W. Laurel
Independence, Kansas 67301
620-331-4099
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Foote Memorial Hospital
205 Northeast Ave
Jackson, Michigan 49201
(517) 788-4800
Foote Memorial Hospital Allegiance Health is a community-owned, locally-governed health system in Jackson, Michigan. We...
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Glacier Oncology, PLLC
75 Claremont St Ste E
Kalispell, Montana 59901
(406) 752-7600
Glacier Oncology, PLLC Glacier Oncology are physician clinics focusing exclusively on the medical subspecialties of...
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Kalispell Regional Medical Center
310 Sunnyview Ln
Kalispell, Montana 59901
(406) 752-5111
Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
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Kadlec Hematology & Oncology
7360 W. Deschutes
Kennewick, Washington 99336
509-783-0144
Columbia Basin Hematology and Oncology Our collaboration with Seattle Cancer Care Alliance gives you convenient...
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Kettering Health Network of Kettering Medical Center
Kettering, Ohio 45429
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Cancer Center of Kansas, PA - Kingman
750 Avenue D West
Kingman, Kansas 67068
(620) 532-3147
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CCOP Holston Valley Medical Center
Kingsport, Tennessee 37662
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University of Tennessee Cancer Institute
Knoxville, Tennessee 37920
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Fairfield Medical Center
401 N Ewing St
Lancaster, Ohio 43130
(740) 687-8000
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Sparrow Regional Cancer Center
1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
Sparrow Regional Cancer Center Sparrow has grown to become the region's largest health system, and...
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Lawrence Memorial Hospital
325 Maine Street
Lawrence, Kansas 66044
(785) 505-5000
Lawrence Memorial Hospital Lawrence Memorial Hospital (LMH), in collaboration with its medical staff, is dedicated...
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Cancer Center of Kansas, PA - Liberal
315 W. 15th St.
Liberal, Kansas 67905
(620) 629-6727
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USC Norris Comprehensive Cancer Center
Los Angeles, California 90089
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Strecker Cancer Center at Marietta Memorial Hospital
401 Matthew St
Marietta, Ohio 45750
(740) 376-5000
Strecker Cancer Center at Marietta Memorial Hospital The Memorial Health System's Strecker Cancer Center combines...
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Tibotec Therapeutics - Division of Ortho Biotech Products, LP
Marysville, California 95901
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St. Francis Hospital & Health Centers
Michigan City, Indiana 46360
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Montana Cancer Specialists at Montana Cancer Center
500 W Broadway St
Missoula, Montana 59807
(406) 728-2539
Montana Cancer Specialists at Montana Cancer Center MCC is a comprehensive medical oncology, hematology and...
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Montana Cancer Center
500 W Broadway St
Missoula, Montana 59802
(406) 543-7271
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center St. Patrick Hospital is...
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Montrose Memorial Hospital Cancer Center
Montrose, Colorado 81401
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Knox Community Hospital
1330 Coshocton Ave
Mount Vernon, Ohio 43050
(740) 393-9000
Knox Community Hospital A community-owned, 115-bed, not-for-profit hospital located in Mount Vernon, Ohio (approximately 40...
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Edward Hospital Cancer Center
Naperville, Illinois 60540
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Licking Memorial Cancer Care Program at Licking Memorial Hospital
1320 West Main Street
Newark, Ohio 43055
(740) 348-4475
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Providence Newberg Medical Center
1001 Providence Dr
Newberg, Oregon 97132
(503) 537-1555
Providence Newberg Medical Center Providence Health & Services in Oregon, ranked as one of the...
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Southwest Virginia Regional Cancer Center at Wellmonth Health
Norton, Virginia 24273
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Highland Hospital
Oakland, California 94602
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Providence St. Peter Hospital Regional Cancer Center
413 Lilly Rd NE
Olympia, Washington 98506
(888) 492-9480
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Chao Family Comprehensive Cancer Center
Orange, California 92868
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Willamette Falls Hospital
Oregon City, Oregon 97045
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Cancer Center of Kansas, PA - Parsons
1902 S. US Hwy 59
Parsons, Kansas 67357
(620) 421-2855
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Valley Medical Oncology Consultants - Pleasanton
Pleasanton, California 94588
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Mercy Regional Cancer Center at Mercy Hospital
2601 Electric Ave
Port Huron, Michigan 48060
(810) 985-1500
Mercy Regional Cancer Center at Mercy Hospital The Mercy Regional Cancer Center at St. Joseph...
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Providence Portland Cancer Center
Portland, Oregon 97213
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Columbia River Oncology Program
Portland, Oregon 97225
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Cancer Center of Kansas, PA - Pratt
124 Commodore, Ste. A
Pratt, Kansas 67124
(620) 672-2478
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St. Mary - Corwin Medical Center
1008 Minnequa Avenue
Pueblo, Colorado 81004
719-557-4000
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Reid Hospital & Health Care Services
1100 Reid Pkwy
Richmond, Indiana 47374
(765) 983-3000
Reid Hospital & Health Care Services As you will see on campus and throughout our...
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Interlakes Oncology/Hematology PC
Rochester, New York 14623
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James P. Wilmot Cancer Center, University of Rochester
Rochester, New York 14642
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Seton Cancer Institute at Saint Mary's - Saginaw
800 S Washington Ave
Saginaw, Michigan 48601
(989) 907-8115
Seton Cancer Institute at Saint Mary's - Saginaw At St. Mary's of Michigan, we continue...
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Mowery Clinic LLC Tammy Walker Cancer Center
Salina, Kansas 67401
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Cancer Center of Kansas, PA - Salina
600 S Santa Fe Ave
Salina, Kansas 67401
(785) 823-1521
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Polyclinic First Hill
Seattle, Washington 98122
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