Effects of Statins on Lower Extremity Arterial Function Assessed by Magnetic Resonance Imaging
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 40 - 90 |
| Updated: | 4/2/2016 |
| Start Date: | July 2007 |
| End Date: | June 2010 |
Cholesterol-lowering drugs called statins improve the functioning of the endothelium, and
help prevent heart disease. We are testing whether statins improve endothelial function more
in the arteries that have worse endothelium to begin with. One of the functions of the
endothelium is to help control how blood vessels dilate (expand) or contract (narrow) in
different situations. This affects how blood flows through those vessels. Magnetic resonance
imaging (MRI) can be used to evaluate endothelial function in the arms and legs
noninvasively. You are being asked to participate in a study using MRI to test whether a
3-week course of statins improves the endothelium of legs more than it improves the
endothelium of arms.
Adults with type 2 diabetes may join.
help prevent heart disease. We are testing whether statins improve endothelial function more
in the arteries that have worse endothelium to begin with. One of the functions of the
endothelium is to help control how blood vessels dilate (expand) or contract (narrow) in
different situations. This affects how blood flows through those vessels. Magnetic resonance
imaging (MRI) can be used to evaluate endothelial function in the arms and legs
noninvasively. You are being asked to participate in a study using MRI to test whether a
3-week course of statins improves the endothelium of legs more than it improves the
endothelium of arms.
Adults with type 2 diabetes may join.
Correct
Inclusion Criteria:
- Age 40-90
- Male or female
- Type 2 diabetes
Exclusion Criteria:
- Known pregnancy or nursing.
- Females of child bearing potential must have been surgically sterilized or be post
menopausal.
- Smoking
- Known vascular disease
- Inability to complete MRI scan
- Symptoms of claudication
- Use of a nitrate medicine
- Use of any cholesterol-lowering agent
- LDL < 70
- Acute illness
- Liver disease
- Contraindication to getting an MRI scan (i.e. electronic implant, shrapnel, cerebral
aneurysm clip, welding history).
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