CC-4047 (Pomalidomide) for Graft vs. Host Disease

Chronic Graft vs. Host Disease is a major complication after allogeneic hematopoietic stem
cell transplantation developing in 30 - 70% of patients. It is a multisystem alloimmune and
autoimmune disorder with a negative impact on quality of life and functional status,
increased need for extended immunosuppression and is the leading cause of late transplant
related mortality.

CC-4047 is a novel immune modulatory drug that is a thalidomide analog with a 4,000 fold
greater inhibition of TNF-α production related to thalidomide. Several features of CC-4047
suggest that this drug may be useful in treating chronic GVHD including in vitro suppression
of TNF-α production, increasing Th1 and stimulation of IL-12 and sIL-Rα.

This study is an open-label, single-arm, pilot study of efficacy and safety of CC-4047 in
patients with advanced chronic GvHD who failed to achieve a response with high-dose
corticosteroids or second line systemic immunosuppressive therapy.

Patient must meet all of the following inclusion criteria:

- Must be greater than or equal to 18 years of age at the time of consent.

- Must be able to adhere to the study visit schedule and other protocol requirements.

- Chronic graft versus host disease (GHVD) developing after allogeneic hematological
stem cell transplantation diagnosed using NIH criteria for diagnosis and staging of
chronic GvHD (including both "classic chronic GvHD" and "overlap syndrome")

- Must have moderate or severe chronic GvHD according to Global Staging System for
Chronic GvHD or mild chronic GvHD with platelet count less than 100 x 109/L

- Must have failed to achieve response to high dose corticosteroid (average 0.5
mg/kg/day prednisone or equivalent for greater than or equal to 8 weeks), or have
failed second line systemic immunosuppressive therapy.

- If taking corticosteroids at the time of enrollment, must be on stable or tapering
schedule without corticosteroid pulses in the preceding 8 weeks.

- If taking secondary systemic immunosuppressive therapy at the time of enrolment, must
be on stable or tapering schedule in the preceding 4 weeks.

- Karnofsky performance score (KPS) greater than or equal to 60%.

- Life expectancy greater than or equal to 3 months.

- Female of childbearing potential (FCBP) must agree to use two reliable forms of
contraception simultaneously or to practice complete abstinence from heterosexual
intercourse for at least 28 days before starting study drug, while participating in
the study, and for at least 28 days after discontinuation from the study. The two
methods of reliable contraception must include one highly effective method (i.e.
intrauterine device (IUD), hormonal [birth control pills, injections, or implants],
tubal ligation, partner's vasectomy) and one additional effective (barrier) method
(i.e. latex condom, diaphragm, cervical cap). FCBP must be referred to a qualified
provider of contraceptive methods if needed.

- FCBP must agree to pregnancy testing and contraceptive counseling every 28 days
during the study. FCBP must also refrain from donating blood and/or egg while
participating in the study and for at least 28 days after discontinuation from this
study

- FCBP must have two negative pregnancy tests (sensitivity of at least 25 mIU/mL) prior
to starting study drug. The first pregnancy test must be performed within 10-14 days
prior to the start of study drug and the second pregnancy test must be performed
within 24 hours prior to the start of study drug.

- Must agree to abstain from breastfeeding during study participation and for at least
28 days after study drug discontinuation.

- Male Subjects must agree to complete abstinence or to use a condom during sexual
contact with with a pregnant female or a female of childbearing potential while
participating in the study and for at least 90 days following study drug
discontinuation even if he has undergone a successful vasectomy

- Must agree to counseling about sexual contact and the potential risks of fetal
exposure to pomalidomide every 28 days.

- Male subjects will be warned that sharing study drug is prohibited

- Must agree to abstain from donating blood for at least 28 days following
discontinuation of the study drug.

- Must agree to abstain from donating semen or sperm during study participation and for
at least 90 days after study drug discontinuation.

- Must agree that if a pregnancy or a positive pregnancy test does occur in a the
partner of a male study subject during study participation, the investigator must be
notified immediately

- Patients must agree to not share study drug with anyone during participation in the
study.

- Must understand and voluntarily sign an informed consent form, or must have a legally
authorized representative who is able and willing to voluntarily sign an informed
consent form on behalf of the patient.

Exclusion Criteria:

- Pregnant or lactating females.

- New immunosuppressive therapy started within the preceding 4 weeks.

- Extracorporeal photopheresis within the preceding 3 months.

- Hypersensitivity to any immune modulator drug (IMiD™).

- Unable to take prophylactic anticoagulation.

- Any condition which places the patient at unacceptable risk if he/she were to
participate in the study or confounds the ability to interpret data from the study.

- Acute, persistent, recurrent or late-onset acute GvHD defined by NIH criteria.

- Any of the following laboratory values at registration:

- absolute neutrophil count (ANC) less than 1.0 x 109/L,

- platelets less than 75 x 109/L, or

- creatinine clearance less than 50 mL/min (Cockroft-Gault formula).

- Uncontrolled infection requiring systemic antibiotics.

- Known human immunodeficiency virus (HIV), hepatitis B virus (HBV) and/or hepatitis C
virus (HCV) infection.

- Known uncontrolled arrhythmias or symptomatic heart disease or left ventricular
ejection fraction less than 40% (an ECHO should be performed as clinically indicated)

- Recurrence of cancer for which the transplant was done except for presence of minimal
residual disease by PCR.

- Other cancer less than or equal to 2 years prior study-entry except:

- Basal cell carcinoma of the skin,

- Squamous cell carcinoma of the skin,

- Carcinoma in situ of the cervix,

- Carcinoma in situ of the breast, or

- Prostate cancer (Tumor, Node, Metastasis [TNM] stage T1a or T1b)