Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study
| Status: | Terminated |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | October 2008 |
| End Date: | May 30, 2017 |
The purpose of this research study is to determine if putting local anesthetic through one or
two percutaneous catheters placed next to the nerves that go to an amputated limb will
decrease long-term pain in the amputated limb.
two percutaneous catheters placed next to the nerves that go to an amputated limb will
decrease long-term pain in the amputated limb.
Specific Aim 1: To determine if, compared with current and customary analgesia, the addition
of multiple-day ambulatory continuous peripheral nerve blocks decrease the incidence and
severity of post-amputation phantom limb and stump pain.
Hypothesis 1: Following upper or lower extremity amputation, the incidence of phantom limb
and/or stump pain will be significantly decreased four weeks following multiple-day
ambulatory continuous peripheral nerve blocks as compared with patients receiving
standard-of-care treatment.
Hypothesis 2: Following upper or lower extremity amputation, the severity of phantom limb
and/or stump pain will be significantly decreased four weeks following multiple-day
ambulatory continuous peripheral nerve blocks as compared with patients receiving
standard-of-care treatment (as measured on the 11-point numeric rating scale).
of multiple-day ambulatory continuous peripheral nerve blocks decrease the incidence and
severity of post-amputation phantom limb and stump pain.
Hypothesis 1: Following upper or lower extremity amputation, the incidence of phantom limb
and/or stump pain will be significantly decreased four weeks following multiple-day
ambulatory continuous peripheral nerve blocks as compared with patients receiving
standard-of-care treatment.
Hypothesis 2: Following upper or lower extremity amputation, the severity of phantom limb
and/or stump pain will be significantly decreased four weeks following multiple-day
ambulatory continuous peripheral nerve blocks as compared with patients receiving
standard-of-care treatment (as measured on the 11-point numeric rating scale).
Inclusion Criteria:
- undergoing unilateral surgical amputation of the upper or lower extremity including at
least one metacarpal or metatarsal bone, respectively
- currently without phantom limb and/or stump pain in a previously-amputated limb
- ages 18 years or older
- desiring perineural infusion for up to 6 days
- willing to have an ambulatory infusion following hospital discharge
Exclusion Criteria:
- hepatic or renal failure
- allergy to the study medications
- pregnancy
- incarceration
- possessing a contraindication to perineural catheter placement or perineural local
anesthetic infusion
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